61869-08-7|Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-Products Supply

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)- cas no:61869-08-7

Synonyms: Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S-trans)-;(-)-Paroxetine;(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine;Aropax;BRL 29060;Besitram;Casbol;FG 7051;Frosinor;Motivan;Paroxetine;PaxPar;Paxetil;Paxil;

Identification

NamePiperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-
CAS61869-08-7
SynonymsPiperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S-trans)-;(-)-Paroxetine;(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine;Aropax;BRL 29060;Besitram;Casbol;FG 7051;Frosinor;Motivan;Paroxetine;PaxPar;Paxetil;Paxil;
Molecular FormulaC₁₉H₂₀FNO₃
Molecular Weight329.365403

Chemical Properties

Appearancewhite to off-white powder
refractive index1.561

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard UN NO.
Safety

RIDADR of Paroxetine (CAS NO.61869-08-7): 3249
HazardClass: 6.1(b)
PackingGroup: III
Experimental reproductive effects. Human systemic effects: changes in sodium levels, changes in urine composition, excitement, hyperglycemia, paresthesis. When heated to decomposition it emits toxic vapors of NO_x and F^?.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	6700ug/kg (6.7mg/kg)	BEHAVIORAL: EXCITEMENT	American Journal of Emergency Medicine. Vol. 11, Pg. 682, 1993.
women	TDLo	oral	400ug/kg (0.4mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS	Journal of Clinical Psychiatry. Vol. 58, Pg. 175, 1997.
women	TDLo	oral	400ug/kg (0.4mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: REGIDITY	British Journal of Psychiatry. Vol. 169, Pg. 522, 1996.
women	TDLo	oral	1400ug/kg/7W- (1.4mg/kg)	?	American Journal of Psychiatry. Vol. 153, Pg. 134, 1996.
women	TDLo	oral	2800ug/kg/7D- (2.8mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION	Medical Journal of Australia. Vol. 163, Pg. 390, 1995.
women	TDLo	oral	4200ug/kg/3W- (4.2mg/kg)	ENDOCRINE: HYPERGLYCEMIA	Annals of Internal Medicine. Vol. 125, Pg. 782, 1996.
women	TDLo	oral	5600ug/kg/2W- (5.6mg/kg)	BEHAVIORAL: WAKEFULNESS BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: IRRITABILITY	Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 36, Pg. 445, 1997.
women	TDLo	oral	8400ug/kg/21D (8.4mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA	Netherlands Journal of Medicine. Vol. 51, Pg. 237, 1997.
women	TDLo	oral	11200ug/kg/8W (11.2mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS	Journal of Clinical Pyschopharmacology. Vol. 16, Pg. 258, 1996.

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Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)- cas no:61869-08-7

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