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Diphemanil cas no:62-97-5

Synonyms: Diphemanil mesylate; Variton; Diphemanil Methylsulfate

Identification
NameDiphemanil
CAS62-97-5
SynonymsDiphemanil mesylate; Variton; Diphemanil Methylsulfate
EINECS(EC#)200-552-4
Molecular FormulaC21H28NO4S
Molecular Weight390.51
Safety Data

Safety

Poison by ingestion, intraperitoneal, and intravenous routes. An anticholinergic agent. When heated to decomposition it emits very toxic fumes of SOx and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 42mg/kg (42mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 576, 1951.
guinea pig LD50 oral 404mg/kg (404mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 576, 1951.
mouse LD50 intraperitoneal 47mg/kg (47mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 576, 1951.
mouse LD50 intravenous 4012ug/kg (4.012mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 103, Pg. 100, 1955.
mouse LD50 oral 317mg/kg (317mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 576, 1951.
rat LD50 intravenous 5mg/kg (5mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 461, 1982.
rat LD50 oral 1107mg/kg (1107mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 576, 1951.

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