1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1) cas no:6202-23-9
Synonyms: 1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (9CI);5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, N,N-dimethyl-,hydrochloride (6CI,7CI,8CI); 10,11d-Amitriptyline hydrochloride; Benzamin; Cyclobenzaprine hydrochloride;Flexeril; Flexiban; Lisseril; MK 130 hydrochloride; Miosan; Proheptatrienehydrochloride; Tensodox; Yurelax
Name1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1)
CAS6202-23-9
Synonyms1-Propanamine,3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (9CI);5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, N,N-dimethyl-,hydrochloride (6CI,7CI,8CI); 10,11d-Amitriptyline hydrochloride; Benzamin; Cyclobenzaprine hydrochloride;Flexeril; Flexiban; Lisseril; MK 130 hydrochloride; Miosan; Proheptatrienehydrochloride; Tensodox; Yurelax
EINECS(EC#)228-264-4
Molecular FormulaC20H21N.HCl
Molecular Weight311.88
AppearanceCrystalline Solid
storage temp-20°C Freezer
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn: Harmful;
Risk R20/21/22
Safety Poison by ingestion and intravenous routes. Human systemic effects: distorted perceptions, euphoria, general anesthetic, hallucinations, pulse rate increase, somnolence, wakefulness. A muscle relaxant. When heated to decomposition it emits very toxic fumes of NOx and HCl.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP0875000
- CHEMICAL NAME :
- 5H-Dibenzo(a,d)cycloheptene-delta(sup
5)-gamma-propylamine, N,N-dimethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 6202-23-9
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C20-H21-N.Cl-H
- MOLECULAR WEIGHT :
- 311.88
- WISWESSER LINE NOTATION :
- L C676 BHJ B3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 5714 ug/kg/2D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness
Behavioral - euphoria
Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press,
Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
Volume(issue)/page/year: 54,39,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1 mg/kg/3D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness
Behavioral - euphoria
Behavioral - hallucinations, distorted perceptions
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press,
Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
Volume(issue)/page/year: 54,39,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptions
Cardiac - pulse rate increase, without fall in BP
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
20,281,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 8400 ug/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - general anesthetic
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press,
Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
Volume(issue)/page/year: 44,151,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,87,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 144,481,1963
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5339
No. of Facilities: 100 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 656 (estimated)
No. of Female Employees: 512 (estimated)
