Yohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)- cas no:6211-32-1
Synonyms: 20a-Yohimban-16b-carboxylic acid, 17a-hydroxy-, methyl ester,monohydrochloride (8CI); Yohimban-16-carboxylic acid, 17-hydroxy-, methylester, monohydrochloride, (16b,17a,20a)- (9CI); NSC 407307; Rauwolscine hydrochloride; a-Yohimbine hydrochloride
NameYohimban-16-carboxylicacid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16b,17a,20a)-
CAS6211-32-1
Synonyms20a-Yohimban-16b-carboxylic acid, 17a-hydroxy-, methyl ester,monohydrochloride (8CI); Yohimban-16-carboxylic acid, 17-hydroxy-, methylester, monohydrochloride, (16b,17a,20a)- (9CI); NSC 407307; Rauwolscine hydrochloride; a-Yohimbine hydrochloride
EINECS(EC#)208-977-7
Molecular FormulaC21H26 N2 O3 . Cl H
Molecular Weight390.90368
Appearancewhite solid
storage tempStore at RT
Hazard T: Toxic;
Risk R23/24/25
Safety
Poison by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also YOHIMBINE.
Hazard Codes of Rauwolscine hydrochloride (CAS NO.503-49-1): 
T
Risk Statements: 23/24/25
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-45
S22:Do not breathe dust.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LDLo |
subcutaneous |
20mg/kg (20mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
"Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932. |
| frog |
LD50 |
parenteral |
200mg/kg (200mg/kg) |
|
Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940. |
| guinea pig |
LD50 |
intraperitoneal |
162mg/kg (162mg/kg) |
|
Bulletin des Sciences Pharmacologiques. Vol. 47, Pg. 33, 1940. |
| mouse |
LDLo |
oral |
125mg/kg (125mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
"Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932. |
| rabbit |
LDLo |
intravenous |
2mg/kg (2mg/kg) |
|
"Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932Vol. -, Pg. -, 1932. |
