Butanamide,4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]- cas no:62666-20-0

NameButanamide,4-[[(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methylene]amino]-
CAS62666-20-0
SynonymsGabren;Gabrene; Halogabide; Progabide; SL 76-002; SL 76002
EINECS(EC#)263-679-4
Molecular FormulaC17H16 Cl F N2 O2
Molecular Weight334.80

refractive index1.59

Safety Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data reported. When heated to decomposition it emits toxic vapors of NOx, F?, and, Cl?.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

EJ3500970

CHEMICAL NAME :

Butanamide, 4-(((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyle ne)amino)-

CAS REGISTRY NUMBER :

62666-20-0

LAST UPDATED :

199612

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C17-H16-Cl-F-N2-O2

MOLECULAR WEIGHT :

334.80

WISWESSER LINE NOTATION :

ZV3NUYR DG&R BQ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1350 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1350 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4094992 ** TUMORIGENIC DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

655 gm/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Endocrine - adrenal cortex tumors

REFERENCE :

LMSED6 L.E.R.S. Monograph Series. Laboratories d'Etudes et de Recherches Synthelabo Monograph Series. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1983- Volume(issue)/page/year: 3,203,1985