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1,3-Benzenedicarboxamide,N1,N3-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo- cas no:62883-00-5

Synonyms: 1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-(9CI);N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarboxamide;

Identification
Name1,3-Benzenedicarboxamide,N1,N3-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-
CAS62883-00-5
Synonyms1,3-Benzenedicarboxamide,N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-(9CI);N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxypropanoyl)amino]-2,4,6-triiodobenzene-1,3-dicarboxamide;
Molecular FormulaC17H22I3N3O8
Molecular Weight777.09
Chemical Properties
refractive index1.731
Safety Data

Safety

Moderately toxic by intracerebral and parenteral routes. Mildly toxic by other routes. Human systemic effects: acute tubular necrosis, change in heart rate, changes in kidney tubules, muscle contraction, muscle weakness. When heated to decomposition it emits very toxic fumes of I and NOx.


Toxicity

1.    

ivn-man TDLo:600 mg/kg/3S-C:BAH

    AIMDAP    Archives of Internal Medicine. 147 (1987),2208.
2.    

ivn-man TDLo:1657 mg/kg:SYS

    AIMEAS    Annals of Internal Medicine. 107 (1987),116.
3.    

orl-rat LD:>49 g/kg

    FRPSAX    Farmaco, Edizione Scientifica. 32 (1977),835.
4.    

ivn-rat LD50:22,044 mg/kg

    ACRAAX    Acta Radiologica. 370 (1987),41.
5.    

iat-rat LD50:13,268 mg/kg

    USXXAM    United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4001323 .
6.    

ipr-mus LD50:40,825 mg/kg

    USXXAM    United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4001323 .
7.    

ivn-mus LD50:33 g/kg

    YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 12 (Suppl 1)(1984),11.
8.    

ice-mus LD50:3 g/kg

    FRPSAX    Farmaco, Edizione Scientifica. 32 (1977),835.
9.    

ivn-dog LD50:35 g/kg

    FRPSAX    Farmaco, Edizione Scientifica. 32 (1977),835.
10.    

ivn-rbt LD50:20 g/kg

    FRPSAX    Farmaco, Edizione Scientifica. 32 (1977),835.

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