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Benzenesulfonamide,4-amino- cas no:63-74-1

Synonyms: Sulfanilamide (SN);Sulfanilamide(8CI);(4-(Aminosulfonyl)phenyl)amine;4-(Aminosulfonyl)aniline;4-Aminobenzenesulfonamide;4-Aminophenylsulfonamide;A-349;Albosal;Ambeside;Antistrept;Astreptine;Bactesid;Deseptyl;Dipron;Ergaseptine;Erysipan;Fourneau 1162;Gombardol;Infepan;NSC 7618;Neococcyl;Orgaseptine;PABS;Prontosil white;PronzinAlbum;Proseptine;Proseptol;Pysococcine;Ro 1-3354;Rubiazol A;Sanamid;Septamide Album;Septanilam;Septinal;Septoplex;Septoplix;Stramid;Strepamide;Strepsan;Streptasol;Streptocid;Streptocid album;Streptocide (white);Streptoclase;Strepton;Streptopan;Streptosil;Sulfamidyl;Sulfana;Sulfanalone;Sulfanidyl;Sulfanil;Sulfanilamide Vaginal Cream;Sulfonamide;Sulfonylamide;Sulphanilamide;Tolder;Whitestreptocide;p-Aminophenylsulfonamide;p-Anilinesulfonamide;p-Sulfamoylaniline;

Identification
NameBenzenesulfonamide,4-amino-
CAS63-74-1
SynonymsSulfanilamide (SN);Sulfanilamide(8CI);(4-(Aminosulfonyl)phenyl)amine;4-(Aminosulfonyl)aniline;4-Aminobenzenesulfonamide;4-Aminophenylsulfonamide;A-349;Albosal;Ambeside;Antistrept;Astreptine;Bactesid;Deseptyl;Dipron;Ergaseptine;Erysipan;Fourneau 1162;Gombardol;Infepan;NSC 7618;Neococcyl;Orgaseptine;PABS;Prontosil white;PronzinAlbum;Proseptine;Proseptol;Pysococcine;Ro 1-3354;Rubiazol A;Sanamid;Septamide Album;Septanilam;Septinal;Septoplex;Septoplix;Stramid;Strepamide;Strepsan;Streptasol;Streptocid;Streptocid album;Streptocide (white);Streptoclase;Strepton;Streptopan;Streptosil;Sulfamidyl;Sulfana;Sulfanalone;Sulfanidyl;Sulfanil;Sulfanilamide Vaginal Cream;Sulfonamide;Sulfonylamide;Sulphanilamide;Tolder;Whitestreptocide;p-Aminophenylsulfonamide;p-Anilinesulfonamide;p-Sulfamoylaniline;
EINECS(EC#)200-563-4
Molecular FormulaC6H8N2O2S
Molecular Weight172.2
Chemical Properties
AppearanceWhite to yellowish crystalline powder
refractive index1.5897 (158 C)
storage temp0-6°C
Safety Data

Hazard UN NO.
Risk R40
HS Code 29350090

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WO8400000
CHEMICAL NAME :
Sulfanilamide
CAS REGISTRY NUMBER :
63-74-1
BEILSTEIN REFERENCE NO. :
0511852
LAST UPDATED :
199701
DATA ITEMS CITED :
30
MOLECULAR FORMULA :
C6-H8-N2-O2-S
MOLECULAR WEIGHT :
172.22
WISWESSER LINE NOTATION :
ZSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 gm/kg/90D-I
TOXIC EFFECTS :
Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
82200 mg/kg/39W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
60 gm/kg/30D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
135 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
DOSE :
974 mg/kg
SEX/DURATION :
female 34-37 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
30 umol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982 *** REVIEWS *** TOXICOLOGY REVIEW JMSHAO Journal of the Mount Sinai Hospital (New York). (New York, NY) V.1-36, 1934-69. For publisher information, see MSJMAZ. Volume(issue)/page/year: 10,343,1943 TOXICOLOGY REVIEW PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1954- Volume(issue)/page/year: 8,413,1961 TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 2(6),13,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84382 No. of Facilities: 149 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 3565 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84382 No. of Facilities: 654 (estimated) No. of Industries: 6 No. of Occupations: 11 No. of Employees: 6529 (estimated) No. of Female Employees: 3131 (estimated)

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