3-Pyridinecarboxylicacid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester cas no:63-75-2

Name3-Pyridinecarboxylicacid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester
CAS63-75-2
SynonymsArecoline(6CI); Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester (8CI);1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester;3-Methoxycarbonyl-1-methyl-1,2,5,6-tetrahydropyridine; Arecaidine methyl ester;Arecolin; Arecoline base; Methyl 1,2,5,6-tetrahydro-1-methylnicotinate; MethylN-methyl-1,2,5,6-tetrahydronicotinate; Methyl arecaidin; Methylarecaidine; NSC56321
EINECS(EC#)200-565-5
Molecular FormulaC8H13NO2
Molecular Weight155.19

refractive index1.483

Safety

Poison by subcutaneous and intraperitoneal routes. Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. It mimics the action of acetylcholine, a neuro-transmitter, and is a parasympathetic nervous system stimulant. Its action on the central nervous system can cause tremors. Human mutation data reported. It is easily nitrosated to several nitrosamines. See also ESTERS and NITROSAMINES. It is the major alkaloid found in betel quid. Combustible, can react with oxidizing materials. When heated to decomposition it emits highly toxic fumes of NO_x.

1.		dnd-hmn:Cells-uns 20 µg/tube		MUREAV    Mutation Research. 278 (1992),271.
2.		dni-hmn:Cells-uns 339 µmol/L		IJCNAW    International Journal of Cancer. 47 (1991),396.
3.		orl-rat LD50:2500 mg/kg		EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 26 (1991),853.
4.		ipr-rat LD50:40 mg/kg		BIJOAK    Biochemical Journal. 113 (1969),123.
5.		orl-mus LD50:550 mg/kg		EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 26 (1991),853.
6.		ipr-mus LD50:190 mg/kg		AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 192 (1971),88.
7.		ivn-mus LD50:36 mg/kg		FATOAO    Farmakologiya i Toksikologiya (Moscow). 28 (1965),33.
8.		unk-mus LDLo:100 mg/kg		HBAMAK    “Abdernalden’s Handbuch der Biologischen Arbeitsmethoden.“ 4 (1935),1289.
9.		scu-dog LD50:5 mg/kg		FAZMAE    Fortschritte der Arzneimittelforschung. 17 (1973),108.
10.		unk-dog LDLo:5 mg/kg		HBAMAK    “Abdernalden’s Handbuch der Biologischen Ar