Benzenemethanamine,N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (1:1) cas no:63-92-3
Synonyms: Benzenemethanamine,N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (9CI);Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride(7CI,8CI); 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride;Dibenzylin; Dibenzyline chloride; Dibenzyline hydrochloride; Dibenzyran; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine,hydrochloride; N-2-Phenoxyisopropyl-N-benzyl-b-chloroethylamine hydrochloride; NSC 37448;Phenoxybenzamine chloride; Phenoxybenzamine hydrochloride
NameBenzenemethanamine,N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (1:1)
CAS63-92-3
SynonymsBenzenemethanamine,N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride (9CI);Benzylamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride(7CI,8CI); 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride;Dibenzylin; Dibenzyline chloride; Dibenzyline hydrochloride; Dibenzyran; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine,hydrochloride; N-2-Phenoxyisopropyl-N-benzyl-b-chloroethylamine hydrochloride; NSC 37448;Phenoxybenzamine chloride; Phenoxybenzamine hydrochloride
EINECS(EC#)200-569-7
Molecular FormulaC18H22 Cl N O . Cl H
Molecular Weight340.29
AppearanceWhite crystalline powder.
storage temp2-8°C
Hazard Xn:Harmful;
Risk R22;R40
Safety
Confirmed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
Hazard Codes:
Xn: Harmful
Risk Statements about Dibenzyline hydrochloride (63-92-3):
R22 Harmful if swallowed.
R40 Limited evidence of a carcinogenic effect.
Safety Statements about Dibenzyline hydrochloride (63-92-3):
S22 Do not breathe dust.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Attention:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
| 1. |
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mmo-sat 3 µg/plate
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EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1. |
| 2. |
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mma-sat 10 µg/plate
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EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1. |
| 3. |
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orl-man TDLo:7143 µg/kg/5D-I:SYS
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AIMEAS Annals of Internal Medicine. 107 (1987),119. |
| 4. |
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orl-rat LDLo:800 mg/kg
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JPETAB Journal of Pharmacology and Experimental Therapeutics. 110 (1954),463. |
| 5. |
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orl-mus LD50:900 mg/kg
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 108 (1956),102. |
| 6. |
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ipr-mus LD50:228 mg/kg
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TXAPA9 Toxicology and Applied Pharmacology. 28 (1974),227. |
| 7. |
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scu-mus LD50:105 mg/kg
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ARZNAD Arzneimittel-Forschung. Drug Research. 17 (1967),305. |
| 8. |
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ivn-mus LD50:63,750 µg/kg
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EJPHAZ European Journal of Pharmacology. 9 (1970),289. |
