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5,5-diphenylhydantoin sodium sigmaultra cas no:630-93-3

Synonyms: Phenytoin Sodium; 5,5-Diphenylhydatoin sodium salt; 4-Ethyloctanoic acid methyl ester

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Identification
Name5,5-diphenylhydantoin sodium sigmaultra
CAS630-93-3
SynonymsPhenytoin Sodium; 5,5-Diphenylhydatoin sodium salt; 4-Ethyloctanoic acid methyl ester
EINECS(EC#)211-148-2
Molecular FormulaC15H11N2NaO2
Molecular Weight274.24981
Chemical Properties
AppearanceWhite powder.
storage tempStorage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area. Chemical carcinogens store below 40C, preferably between 15 and 30C, unless otherwise specified by manufacturer. Store in a tight container. Protect from freezing.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn:Harmful;
Risk R22;R43;R62;R63
Safety

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
Safety Information of?Dilantin (CAS NO.630-93-3):
Hazard Codes :?HarmfulXn?
Risk Statements?: 22-43-62-63?(? Harmful if swallowed;May cause sensitization by skin contact;Possible risk of impaired fertility?;Possible risk of harm to the unborn child? )Safety Statements?: 22-36/37/39-45?(Do not breathe dust?;Wear suitable protective clothing, gloves and eye/face protection?; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?)?
RIDADR?: UN 2811 6.1/PG 3
WGK Germany?: 3
RTECS?:MU1400000
HazardClass?: 6.1(b)
PackingGroup:III
?


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 90mg/kg (90mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: HEMORRHAGE		 Archives of Pathology. Vol. 28, Pg. 761, 1939.
guinea pig LD50 subcutaneous 280mg/kg (280mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
guinea pig LDLo intravenous 38600ug/kg (38.6mg/kg) ? Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
man LDLo intravenous 7143ug/kg/14M (7.143mg/kg) CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 American Journal of Emergency Medicine. Vol. 6, Pg. 255, 1988.
man LDLo intravenous 12571ug/kg/25 (12.571mg/kg) CARDIAC: PULSE RATE

CARDIAC: OTHER CHANGES

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 American Journal of Emergency Medicine. Vol. 6, Pg. 255, 1988.
man LDLo oral 647mg/kg/21W- (647mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Archives of Internal Medicine. Vol. 81, Pg. 605, 1948.
man LDLo unreported 29mg/kg (29mg/kg) ? "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 70mg/kg/17D-I (70mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"		 New England Journal of Medicine. Vol. 242, Pg. 897, 1950.
mouse LD50 intraperitoneal 103mg/kg (103mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 12, 1980.
mouse LD50 intravenous 98mg/kg (98mg/kg) ? Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse LD50 oral 165mg/kg (165mg/kg) ? Indian Journal of Experimental Biology. Vol. 19, Pg. 1047, 1981.
mouse LD50 subcutaneous 400mg/kg (400mg/kg) ? Biochemical Pharmacology. Vol. 17, Pg. 369, 1968.
mouse LD50 unreported 540mg/kg (540mg/kg) ? United States Patent Document. Vol. #4056540,
rabbit LDLo intravenous 157mg/kg (157mg/kg) ? Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 intraperitoneal 138mg/kg (138mg/kg) ? Indian Journal of Physiology and Pharmacology. Vol. 10, Pg. 5, 1966.
rat LD50 intravenous 90mg/kg (90mg/kg) ? Acta Pharmaceutica Jugoslavica. Vol. 37, Pg. 123, 1987.
rat LD50 oral 1530mg/kg (1530mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 138, Pg. 224, 1962.
rat LD50 subcutaneous 230mg/kg (230mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 377, 1960.
rat LD50 unreported 153mg/kg (153mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 253, 1962.
women LDLo oral 78mg/kg (78mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Archives of Dermatology and Syphilology. Vol. 46, Pg. 856, 1942.
women TDLo oral 4mg/kg/D (4mg/kg) ENDOCRINE: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 JAMA, Journal of the American Medical Association. Vol. 176, Pg. 491, 1961.
women TDLo oral 148mg/kg/28D- (148mg/kg) BEHAVIORAL: HEADACHE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"		 Archives of Neurology and Psychiatry. Vol. 45, Pg. 769, 1941.

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