Berberine hydrochloride cas no:633-65-8
Synonyms: NSC 646666;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride (9CI);Berberine, chloride (6CI,7CI);Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride (8CI);Berberinium chloride;
NameBerberine hydrochloride
CAS633-65-8
SynonymsNSC 646666;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-, chloride (9CI);Berberine, chloride (6CI,7CI);Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride (8CI);Berberinium chloride;
EINECS(EC#)211-195-9
Molecular FormulaC20H18NO4.Cl
Molecular Weight371.82
Appearanceyellow crystalline powder
storage tempKeep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn: Harmful;
Risk R20/21/22
Safety
Safety Information of Berberine hydrochloride (CAS NO.633-65-8):
Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38??
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1544
WGK Germany: 2
RTECS: DR9866400
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
37mg/kg (37mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 253, 1952. |
| mouse |
LD50 |
oral |
> 29586mg/kg (29586mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974. |
| mouse |
LD50 |
unreported |
30mg/kg (30mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 22, Pg. 856, 1988. |
| rat |
LD50 |
intravenous |
60mg/kg (60mg/kg) |
? |
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 335, 1990. |
| rat |
LD50 |
oral |
> 15gm/kg (15000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 654, 1974. |
