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Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, hydrochloride (1:1) cas no:637-32-1

Synonyms: Biguanide,1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride (8CI); Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, monohydrochloride (9CI);1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride; 3359 RP; Chloroguanidehydrochloride; Chloroquanil; Diguanyl; Drinupal; Drinupal hydrochloride; Guanatol;Guanatol hydrochloride; M 4888; Paludrine; Paludrine hydrochloride; Palusil;Palusil hydrochloride; Proguanil hydrochloride; RP 3359; SN 12,837; SN 12837;Tirian; Tirian hydrochloride

Identification
NameImidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, hydrochloride (1:1)
CAS637-32-1
SynonymsBiguanide,1-(p-chlorophenyl)-5-isopropyl-, monohydrochloride (8CI); Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, monohydrochloride (9CI);1-(p-Chlorophenyl)-5-isopropylbiguanide hydrochloride; 3359 RP; Chloroguanidehydrochloride; Chloroquanil; Diguanyl; Drinupal; Drinupal hydrochloride; Guanatol;Guanatol hydrochloride; M 4888; Paludrine; Paludrine hydrochloride; Palusil;Palusil hydrochloride; Proguanil hydrochloride; RP 3359; SN 12,837; SN 12837;Tirian; Tirian hydrochloride
EINECS(EC#)211-283-7
Molecular FormulaC11H16 Cl N5 . Cl H
Molecular Weight290.23
Chemical Properties
storage temp-20°C Freezer
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Safety

Poison by ingestion and intravenous routes. Experimental reproductive effects. An antimalarial drug. When heated to decomposition it emits very toxic fumes of Cl and NOx.Safety information of Proguanil hydrochloride (CAS NO.637-32-1):
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III


Toxicity
1.    

orl-rat LD50:58 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
2.    

ivn-rat LD50:33 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
3.    

orl-mus LD50:27 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
4.    

ivn-mus LD50:23 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
5.    

orl-rbt LD50:172 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.
6.    

ivn-rbt LD50:44,850 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
7.    

ivn-gpg LD50:39,510 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),157.
8.    

orl-ckn LD50:400 mg/kg

    BJPCAL    British Journal of Pharmacology and Chemotherapy. 2 (1947),181.

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