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Pramoxine hydrochloride cas no:637-58-1

Synonyms: Morpholine,4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (9CI);Morpholine, 4-[3-(p-butoxyphenoxy)propyl]-,hydrochloride (7CI,8CI);Pramoxine hydrochloride (6CI);4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride;Pramocainehydrochloride;Proctofoam;Tronolaine;Tronothan;Tronothane;Tronothanehydrochloride;

Identification
NamePramoxine hydrochloride
CAS637-58-1
SynonymsMorpholine,4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (9CI);Morpholine, 4-[3-(p-butoxyphenoxy)propyl]-,hydrochloride (7CI,8CI);Pramoxine hydrochloride (6CI);4-[3-(p-Butoxyphenoxy)propyl]morpholine hydrochloride;Pramocainehydrochloride;Proctofoam;Tronolaine;Tronothan;Tronothane;Tronothanehydrochloride;
EINECS(EC#)211-293-1
Molecular FormulaC17H28ClNO3
Molecular Weight329.87
Chemical Properties
AppearanceWhite or off white crystalline powder
Safety Data

Hazard Xi:Irritant
Risk R22;R36/37/38
Safety

Hazard Codes: IrritantXi,HarmfulXn
Risk Statements: 22-36/37/38
R22:Harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RTECS: QD8750000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 109mg/kg (109mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CARDIAC OUTPUT

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
mouse LD50 intraperitoneal 460mg/kg (460mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse LD50 intravenous 79500ug/kg (79.5mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 454, 1959.
mouse LD50 oral 1050mg/kg (1050mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.
mouse LD50 subcutaneous 1470mg/kg (1470mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CARDIAC OUTPUT

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Anesthesie, Analgesie, Reanimation. Vol. 14, Pg. 225, 1957.
rabbit LD50 intravenous 39mg/kg (39mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 99, 1969.

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George Uhe Company
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