PHYSOSTIGMINE SULFATE cas no:64-47-1

NamePHYSOSTIGMINE SULFATE
CAS64-47-1
Synonyms(3as-cis)-amate(estersulfate(2:1)(salt);(3as-cis)-ylcarbamate(estersulfate(2:1);3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth;eserinesulphate;physostigmineso4;physostigminesulphate;ESERINE SULFATE;ESERINE HEMISULFATE
EINECS(EC#)200-585-4
Molecular FormulaC₃₀H₄₂N₆O₄S
Molecular Weight646.84

storage temp2-8°C

Hazardclass6.1(a)

Hazard T+
Risk 26/28
Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by subcutaneous route: hallucinations or distorted perceptions; nausea or vomiting, and other gastrointestinal changes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and SO_x. See also PHYSOSTIGMINE.
Hazard Codes of Physostigmine sulfate (CAS NO.64-47-1): T+
Risk Statements: 26/28 
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 25-45 
S25:Avoid contact with eyes. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	subcutaneous	1250ug/kg (1.25mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
frog	LDLo	parenteral	325mg/kg (325mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
frog	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 547, 1949.
man	TDLo	subcutaneous	191ng/kg (0.000191mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES	Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 53, Pg. 313, 1905.
mouse	LD50	intraperitoneal	510ug/kg (0.51mg/kg)		Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972.
mouse	LD50	intravenous	178ug/kg (0.178mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03167,
mouse	LD50	oral	1680ug/kg (1.68mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 137, 1972.
mouse	LD50	subcutaneous	700ug/kg (0.7mg/kg)		Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953.
rabbit	LDLo	subcutaneous	1500ug/kg (1.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 95, 1932.
rat	LD50	intraperitoneal	1621ug/kg (1.621mg/kg)		Fundamental and Applied Toxicology. Vol. 4, Pg. S195, 1984.
rat	LD50	intravenous	450ug/kg (0.45mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 259, Pg. 153, 1982.
rat	LD50	oral	4mg/kg (4mg/kg)		Annales Pharmaceutiques Francaises. Vol. 11, Pg. 286, 1953.