2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)- cas no:64-73-3
Synonyms: 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-;6-Demethyl-7-chlorotetracyclinehydrochloride;7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamidemonohydrochloride;7-Chloro-6-demethyltetracycline hydrochloride;Clortetrin;Declomycin;Declomycin hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride;Demetraciclina;Detravis;Ledermycinhydrochloride;Meciclin;
Name2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
CAS64-73-3
Synonyms2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-;6-Demethyl-7-chlorotetracyclinehydrochloride;7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamidemonohydrochloride;7-Chloro-6-demethyltetracycline hydrochloride;Clortetrin;Declomycin;Declomycin hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride;Demetraciclina;Detravis;Ledermycinhydrochloride;Meciclin;
EINECS(EC#)200-592-2
Molecular FormulaC21H22Cl2N2O8
Molecular Weight501.32
AppearanceYellow solid
storage temp−20°C
Hazard Xi:Irritant;
Risk R43
Safety
Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: depressed renal function tests, urine composition changes, weight loss or decreased weight gain. Human female reproductive effects by an unreported route: delayed effects on newborn. An antibacterial agent. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl−.
Hazard Codes: Xi
Xi: Irritant
Risk Statements: 43
43: May cause sensitization by skin contact
Safety Statements: 36/37
36/37: Wear suitable protective clothing and gloves
F 8-10-21
F 8: Photosensitive
F 10: Keep under argon
F 21: Sensitive to humidity
| 1. |
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orl-man TDLo:69 mg/kg/4D-I:SYS
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AJKDDP American Journal of Kidney Diseases. 5 (1985),270. |
| 2. |
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orl-rat LD50:2372 mg/kg
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TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185. |
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ivn-rat LD50:94 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews .(ADIS Press Ltd.,Wanchai, Hong Kong.: )1990,704. |
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orl-mus LD50:2150 mg/kg
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DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews .(ADIS Press Ltd.,Wanchai, Hong Kong.: )1990,704. |
| 5. |
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ivn-mus LD50:275 mg/kg
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AISMAE Archivio Italiano di Scienze Mediche Tropical e di Parassitologia. Italian Archives of the Science of Tropical Medicine and Parasitology. 43 (1962),143. |
