64241-34-5|Hydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl esterProducts Supply

Hydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester cas no:64241-34-5

Synonyms: CGP 18684E;Cadral; Cadralazine; Cadraten; Cadrilan; DC 826; ISF 2469; Presmode

Identification

NameHydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester
CAS64241-34-5
SynonymsCGP 18684E;Cadral; Cadralazine; Cadraten; Cadrilan; DC 826; ISF 2469; Presmode
Molecular FormulaC12H21 N5 O3
Molecular Weight283.38

Chemical Properties

refractive index1.59

Safety Data

Safety

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	400mg/kg (400mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section kidney, ureter, and bladder: changes in blood vessels or in circulation of kidney	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
dog	LD50	oral	> 2gm/kg (2000mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	intraperitoneal	362mg/kg (362mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	intravenous	162mg/kg (162mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	oral	825mg/kg (825mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
mouse	LD50	subcutaneous	1420mg/kg (1420mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) lungs, thorax, or respiration: dyspnea	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987.
rat	LD50	intraperitoneal	440mg/kg (440mg/kg)		Drugs of the Future. Vol. 7, Pg. 382, 1982.
rat	LD50	intravenous	269mg/kg (269mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
rat	LD50	oral	2060mg/kg (2060mg/kg)	cardiac: change in rate vascular: bp lowering not characterized in autonomic section	Journal of Cardiovascular Pharmacology. Vol. 3, Pg. 455, 1981.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) liver: other changes	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 15, Pg. 3839, 1987

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Hydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester cas no:64241-34-5

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