64318-79-2|Prosta-2,13-dien-1-oicacid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11a,13E,15R)-Products Supply

Prosta-2,13-dien-1-oicacid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11a,13E,15R)- cas no:64318-79-2

Synonyms: 16,16-Dimethyl-trans-D2-PGE methyl ester;16,16-Dimethyl-trans-D2-PGE1 methyl ester; 16,16-Dimethyl-trans-D2-prostaglandin E1 methyl ester; Carprost; Cergem;Cervagem; Cervageme; Gemeprost; Methyl 16,16-dimethyl-trans-D2-PGE1; ONO 802; Preglandin; SC37681; trans-2,3-Didehydro-16,16-dimethyl PGE1 methyl ester

Identification

NameProsta-2,13-dien-1-oicacid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11a,13E,15R)-
CAS64318-79-2
Synonyms16,16-Dimethyl-trans-D2-PGE methyl ester;16,16-Dimethyl-trans-D2-PGE1 methyl ester; 16,16-Dimethyl-trans-D2-prostaglandin E1 methyl ester; Carprost; Cergem;Cervagem; Cervageme; Gemeprost; Methyl 16,16-dimethyl-trans-D2-PGE1; ONO 802; Preglandin; SC37681; trans-2,3-Didehydro-16,16-dimethyl PGE1 methyl ester
EINECS(EC#)264-775-9
Molecular FormulaC23H38 O5
Molecular Weight394.61

Chemical Properties

refractive index1.533

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Safety

Poison by ingestion, subcutaneous, intravenous, and intravaginal routes. Human reproductive effects by intravaginal route: abortion, changes in the uterus, cervix, and vagina. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes. See other prostaglandin entries.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Toxic information about Cervagem (CAS NO.64318-79-2) is:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravaginal	36mg/kg (36mg/kg)	gastrointestinal: "hypermotility, diarrhea"	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
mouse	LD50	intravenous	29500ug/kg (29.5mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: ataxia lungs, thorax, or respiration: respiratory depression	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
mouse	LD50	oral	59mg/kg (59mg/kg)	behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression gastrointestinal: "hypermotility, diarrhea"	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
mouse	LD50	subcutaneous	32500ug/kg (32.5mg/kg)	behavioral: altered sleep time (including change in righting reflex) lungs, thorax, or respiration: respiratory depression	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
rat	LD50	intravaginal	32500ug/kg (32.5mg/kg)	gastrointestinal: "hypermotility, diarrhea"	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
rat	LD50	intravenous	28600ug/kg (28.6mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: ataxia lungs, thorax, or respiration: respiratory depression	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
rat	LD50	oral	56500ug/kg (56.5mg/kg)	behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: respiratory depression gastrointestinal: "hypermotility, diarrhea"	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.
rat	LD50	subcutaneous	22600ug/kg (22.6mg/kg)	behavioral: altered sleep time (including change in righting reflex) lungs, thorax, or respiration: respiratory depression	Gendai Iryo. Modern Medical Care. Vol. 14, Pg. 188, 1982.

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Prosta-2,13-dien-1-oicacid, 11,15-dihydroxy-16,16-dimethyl-9-oxo-, methyl ester, (2E,11a,13E,15R)- cas no:64318-79-2

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