64490-92-2|Sodium tolmetin dihydrateProducts Supply

Sodium tolmetin dihydrate cas no:64490-92-2

Synonyms: 1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate (9CI);1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, hydrate (1:1:2);Tolmetin sodium;Tolumetin sodium dihydrate;

Identification

NameSodium tolmetin dihydrate
CAS64490-92-2
Synonyms1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate (9CI);1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, hydrate (1:1:2);Tolmetin sodium;Tolumetin sodium dihydrate;
Molecular FormulaC₁₅H₁₈NNaO₅
Molecular Weight315.33

Chemical Properties

Appearancecrystalline solid
storage temp-20°C Freezer

Safety Data

Hazard Xn: Harmful;
Risk R22;R38
Safety

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and Na₂O. See also SODIUM TOLMETIN.
Hazard Codes: Harmful Xn
Risk Statements: 22-38
R22:Harmful if swallowed.
R38:Irritating to skin.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: UX9280000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	550mg/kg (550mg/kg)		European Patent Application. Vol. #134763,
mouse	LD50	intravenous	> 622mg/kg (622mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
mouse	LD50	oral	899mg/kg (899mg/kg)		European Patent Application. Vol. #134763,
mouse	LD50	subcutaneous	670mg/kg (670mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
rat	LD50	intraperitoneal	612mg/kg (612mg/kg)		European Patent Application. Vol. #134763,
rat	LD50	intravenous	> 724mg/kg (724mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.
rat	LD50	oral	914mg/kg (914mg/kg)		European Patent Application. Vol. #134763,
rat	LD50	subcutaneous	1050mg/kg (1050mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1099, 1977.

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Sodium tolmetin dihydrate cas no:64490-92-2

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