dog |
LD50 |
oral |
> 20gm/kg (20000mg/kg) |
|
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
mouse |
LD50 |
intraperitoneal |
609mg/kg (609mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
mouse |
LD50 |
intravenous |
131mg/kg (131mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
mouse |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
|
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
mouse |
LD50 |
subcutaneous |
1130mg/kg (1130mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
rat |
LD50 |
intraperitoneal |
1680mg/kg (1680mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
rat |
LD50 |
intravenous |
105mg/kg (105mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
rat |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
|
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |
rat |
LD50 |
subcutaneous |
3900mg/kg (3900mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 61, 1982. |