2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-, hydrochloride (1:1) cas no:6452-73-9

Name2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]-, hydrochloride (1:1)
CAS6452-73-9
Synonyms2-Propanol,1-[(1-methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-, hydrochloride (9CI);2-Propanol, 1-[o-(allyloxy)phenoxy]-3-(isopropylamino)-, hydrochloride(7CI,8CI); (?à)-1-[o-(Allyloxy)phenoxy]-3-isopropylamino-2-propanolhydrochloride; (?à)-Ba39089; (?à)-Oxprenolol hydrochloride;1-(2-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(2'-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride;1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride;1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propranol-hydrochloride; 1-Isopropyl-amino-2-hydroxy-3-(O-allyloxyphenoxy)propanehydrochloride; 1-Isopropylamino-3-(o-allyloxyphenoxy)-2-propanol hydrochloride;Ba 39089; CIBA 39089Ba; Laracor; Oxiprenolol hydrochloride; Oxprenololhydrochloride; Paritane; Slow-Pren; Slow-Trasicor; Trasacor; Trasicor; Trasicor80; dl-Alprenolol hydrochloride; dl-Oxprenolol hydrochloride
EINECS(EC#)229-260-5
Molecular FormulaC15H23 N O3 . Cl H
Molecular Weight301.46

AppearanceWhite Solid
storage tempStore at +4°C

HazardclassIRRITANT

Hazard Xi
Safety

Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic experimentally by subcutaneous route. Experimental reproductive effects. A beta-adrenergic blocker. When heated to decomposition it emits toxic fumes of NO_x and HCl. See also ALLYL COMPOUNDS and AMINES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD90	oral	200mg/kg (200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA CARDIAC: PULSE RATE	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
dog	LD50	intravenous	15mg/kg (15mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1890, 1970.
dog	LDLo	oral	> 30mg/kg (30mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
dog	LDLo	subcutaneous	> 30mg/kg (30mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
mouse	LD50	intraperitoneal	170mg/kg (170mg/kg)	BEHAVIORAL: SLEEP BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Polish Journal of Pharmacology and Pharmacy. Vol. 25, Pg. 151, 1973.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC	Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
mouse	LD50	oral	520mg/kg (520mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3131, 1973.
mouse	LD50	subcutaneous	245mg/kg (245mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
rabbit	LDLo	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1890, 1970.
rat	LD50	intraperitoneal	147mg/kg (147mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 3131, 1973.
rat	LD50	intravenous	33mg/kg (33mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
rat	LD50	oral	214mg/kg (214mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 1236, 1985.
rat	LD50	subcutaneous	940mg/kg (940mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 164, 1968.
women	LDLo	oral	90mg/kg (90mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	British Medical Journal. Vol. 1, Pg. 552, 1977.
women	TDLo	oral	160mg/kg (160mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA VASCULAR: SHOCK	Human & Experimental Toxicology. Vol. 9, Pg. 101, 1990.