Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-,2-pyridinylmethyl ester cas no:64622-45-3

NameBenzeneacetic acid, a-methyl-4-(2-methylpropyl)-,2-pyridinylmethyl ester
CAS64622-45-3
SynonymsBE100; Ibuprofen piconol; Pimeprofen; Staderm; U 75630; Vesicum
EINECS(EC#)264-979-8
Molecular FormulaC19H23 N O2
Molecular Weight297.43

Safety

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. A skin and eye irritant. When heated to decomposition Ibuprofen piconol (CAS NO.64622-45-3) emits toxic fumes of NO_x. See also p-ISOBUTYLHYDRATROPIC ACID (IBUPROFEN).

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 4gm/kg (4000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
dog	LD50	subcutaneous	986mg/kg (986mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
mouse	LD50	intraperitoneal	709mg/kg (709mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
mouse	LD50	oral	1980mg/kg (1980mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
mouse	LD50	subcutaneous	1250mg/kg (1250mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
rat	LD50	intraperitoneal	1410mg/kg (1410mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
rat	LD50	oral	1440mg/kg (1440mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED CTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.
rat	LD50	subcutaneous	1400mg/kg (1400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 691, 1982.