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3,4-Pyridinedimethanol,5-hydroxy-6-methyl- cas no:65-23-6

Synonyms: Pyridoxol(8CI);2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;Adermin;Bezatin;Pirivitol;Pyridoxin;VB6;

Identification
Name3,4-Pyridinedimethanol,5-hydroxy-6-methyl-
CAS65-23-6
SynonymsPyridoxol(8CI);2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine;2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine;5-Hydroxy-6-methyl-3,4-pyridinedimethanol;Adermin;Bezatin;Pirivitol;Pyridoxin;VB6;
EINECS(EC#)200-603-0
Molecular FormulaC8H11NO3
Molecular Weight169.20
Chemical Properties
Appearancecrystalline solid
storage temp2-8°C
Safety Data

Hazard Xi
Risk R36/37/38
Safety

Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: ataxia, local anesthetic, paresthesia. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS of Pyridoxine (CAS NO.65-23-6): UV1350000


HS Code 29362500

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 5143mg/kg/17W (5143mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC New England Journal of Medicine. Vol. 309, Pg. 445, 1983.
mouse LD50 intraperitoneal 966mg/kg (966mg/kg)   Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977.
mouse LD50 intravenous 545mg/kg (545mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960.
rat LD50 intraperitoneal 1500mg/kg (1500mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964.
rat LD50 intravenous 657mg/kg (657mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940.
rat LD50 oral 4gm/kg (4000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
rat LD50 subcutaneous 3100mg/kg (3100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.
women TDLo oral 139mg/kg/5Y-I (139mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS New England Journal of Medicine. Vol. 311, Pg. 986, 1984.
women TDLo oral 2100mg/kg/30D (2100mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: ATAXIA
Neurology. Vol. 35, Pg. 1466, 1985.
women TDLo oral 4800mg/kg/17W (4800mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC New England Journal of Medicine. Vol. 309, Pg. 445, 1983.
 

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