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Avermectin A1a,5-O-demethyl- cas no:65195-55-3

Synonyms: Antibiotic C 076B1a;L676863;

Identification
NameAvermectin A1a,5-O-demethyl-
CAS65195-55-3
SynonymsAntibiotic C 076B1a;L676863;
EINECS(EC#)265-610-3
Molecular FormulaC48H72O14
Molecular Weight873.07688
Chemical Properties
Appearancewhite crystalline powder
refractive index1.571
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard A poison by ingestion. Moderately toxic by skin contact.
Safety A poison by ingestion. Moderately toxic by skin contact. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CL1200000
CHEMICAL NAME :
Avermectin A1a, 5-O-demethyl-
CAS REGISTRY NUMBER :
65195-55-3
LAST UPDATED :
199706
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C48-H72-O14
MOLECULAR WEIGHT :
873.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD20 - Lethal Dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 32,94,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 32,94,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 42,1786,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 32,94,1984

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