Benzeneacetic acid, a-hydroxy-a-phenyl-,1-azabicyclo[2.2.2]oct-3-yl ester cas no:6581-06-2

NameBenzeneacetic acid, a-hydroxy-a-phenyl-,1-azabicyclo[2.2.2]oct-3-yl ester
CAS6581-06-2
SynonymsBenzilicacid, 3-quinuclidinyl ester (6CI,7CI,8CI); 3-Quinuclidinol, benzilate (ester)(8CI); 3-Hydroxyquinuclidine benzilate; 3-Oxyquinuclidine benzilate;3-Quinuclidinol benzilate; 3-Quinuclidinyl benzilate; 3-Quinuclidyl benzilate;Agent BZ; BZ; BZ (chemical warfare agent); NSC 173698; QNB; Ro 2-3308; b-Quinuclidinyl benzilate
Molecular FormulaC21H23 N O3
Molecular Weight337.45

refractive index1.637
storage temp2-8°C

Hazard Xn
Risk 22
Safety Poison by intravenous route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DD4638000

CHEMICAL NAME :

Benzilic acid, 3-quinuclidinyl ester

CAS REGISTRY NUMBER :

6581-06-2

LAST UPDATED :

199604

DATA ITEMS CITED :

9

MOLECULAR FORMULA :

C21-H23-N-O3

MOLECULAR WEIGHT :

337.45

WISWESSER LINE NOTATION :

T66 A B CNTJ AOVXQR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

4500 ng/kg

TOXIC EFFECTS :

Cardiac - change in rate

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human

DOSE/DURATION :

4800 ng/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - local anesthetic Behavioral - hallucinations, distorted perceptions Behavioral - ataxia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human

DOSE/DURATION :

5 ug/kg

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions Behavioral - ataxia Gastrointestinal - nausea or vomiting

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

103 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Dominant lethal test

MUTATION DATA

TEST SYSTEM :

Rodent - hamster

DOSE/DURATION :

40 mg/kg/6H (Intermittent)

REFERENCE :

ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 17,253,1975