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STRYCHNINE MONONITRATE cas no:66-32-0

Synonyms: Strychninenitrate;98.5%

Identification
NameSTRYCHNINE MONONITRATE
CAS66-32-0
SynonymsStrychninenitrate;98.5%
EINECS(EC#)200-627-1
Molecular FormulaC21H22N2O2•HNO3
Molecular Weight397.47
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T+: Very toxic;
Risk R26/27/28
Safety

Hazard Codes:  T+
Risk Statements : 26/27/28
26/27/28:  Strychnine mononitrate (66-32-0) is very Toxic by inhalation, in contact with skin and if swallowed
Safety Statements : 22-36/37/39-45
22:  Do not breathe dust
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:When Strychnine  mononitrate (66-32-0) used,wear suitable protective clothing, gloves and eye/face protection
RIDADR : UN 1692 6.1/PG 1
WGK Germany:  3
RTECS : WL2450000
HazardClass:  6.1(a).


Toxicity

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

cat

LDLo

oral

2mg/kg (2mg/kg)

 

Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.

dog

LDLo

oral

1gm/kg (1000mg/kg)

 

Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.

guinea pig

LDLo

intraarterial

1200ug/kg (1.2mg/kg)

 

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.

guinea pig

LDLo

intravenous

1mg/kg (1mg/kg)

 

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.

human

LDLo

oral

500ug/kg (0.5mg/kg)

 

Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.

mouse

LD50

oral

930ug/kg (0.93mg/kg)

 

Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 425, 1984.

mouse

LD50

unreported

900ug/kg (0.9mg/kg)

 

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 207, Pg. 688, 1949.

mouse

LDLo

intravenous

600ug/kg (0.6mg/kg)

behavioral: convulsions or effect on seizure threshold

Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970.

mouse

LDLo

subcutaneous

2mg/kg (2mg/kg)

behavioral: convulsions or effect on seizure threshold

Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 458, 1967.

pig

LDLo

oral

20ug/kg (0.02mg/kg)

 

Yakkyoku. Pharmacy. Vol. 28, Pg. 329, 1977.

rabbit

LD50

intravenous

250ug/kg (0.25mg/kg)

behavioral: convulsions or effect on seizure threshold

Pharmacology and Toxicology. English translation of FATOAO. Vol. 21, Pg. 1, 1958.

rat

LD50

oral

16200ug/kg (16.2mg/kg)

 

Drugs in Japan Vol. 6, Pg. 377, 1982.

rat

LDLo

intravenous

600ug/kg (0.6mg/kg)

behavioral: convulsions or effect on seizure threshold

Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1778, 1970.

rat

LDLo

subcutaneous

3mg/kg (3mg/kg)

behavioral: convulsions or effect on seizure threshold
behavioral: tetany

Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 187, Pg. 607, 1937

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