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Home > products > 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-,(2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-,(2S,5R,6R)- cas no:66-79-5

Synonyms: 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, [2S-(2a,5a,6b)]-; 5-Methyl-3-phenyl-4-isooxazolylpenicillin;5-Methyl-3-phenyl-4-isoxazolylpenicillin;6-(5-Methyl-3-phenyl-4-isoxazolyl)aminopenicillanic acid; MPI-penicillin;MPi-PC; Oxacillin; Oxazocillin; Oxazocilline; Penicillin,(5-methyl-3-phenyl-4-isoxazolyl)-; Prostaphlyn

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Identification
Name4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-,(2S,5R,6R)-
CAS66-79-5
Synonyms4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo- (8CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, [2S-(2a,5a,6b)]-; 5-Methyl-3-phenyl-4-isooxazolylpenicillin;5-Methyl-3-phenyl-4-isoxazolylpenicillin;6-(5-Methyl-3-phenyl-4-isoxazolyl)aminopenicillanic acid; MPI-penicillin;MPi-PC; Oxacillin; Oxazocillin; Oxazocilline; Penicillin,(5-methyl-3-phenyl-4-isoxazolyl)-; Prostaphlyn
EINECS(EC#)200-635-5
Molecular FormulaC19H19 N3 O5 S
Molecular Weight441.42
Chemical Properties
Appearancewhite to off white free flowing crystalline powder
Safety Data

Hazard UN NO.
Safety

Poison by an unspecified route. Moderately toxic by ingestion and intravenous routes. Human systemic effects: angranulocytosis. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also PENICILLIN; PENICILLIN compounded with CHOLINE CHLORIDE; PENICILLIN G BENETHAMINE; PENICILLIN G EPHEDRINE SALT; PENICILLIN G PROCAINE.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo intravenous 2550mg/kg/17D (2550mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 90, Pg. 668, 1977.
guinea pig LD50 unreported 120mg/kg (120mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
infant TDLo intravenous 3800mg/kg/19D (3800mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 89, Pg. 769, 1976.
man TDLo intravenous 3800mg/kg/19D (3800mg/kg) blood: agranulocytosis Journal of Pediatrics. Vol. 89, Pg. 769, 1976.
mouse LD50 intravenous 1490mg/kg (1490mg/kg)   Pharmaceutical Chemistry Journal Vol. 1, Pg. 245, 1967.
mouse LD50 oral 6500mg/kg (6500mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 95, 1982.
mouse LD50 unreported 28gm/kg (28000mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
rat LD50 unreported 10gm/kg (10000mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
women TDLo intravenous 40mg/kg/7H-I (40mg/kg) skin and appendages (skin): "dermatitis, other: after systemic exposure" Annals of Pharmacotherpy. Vol. 33, Pg. 1060, 1999.
women TDLo intravenous 5560mg/kg/20D (5560mg/kg) blood: agranulocytosis Southern Medical Journal. Vol. 70, Pg. 1245, 1977.
women TDLo oral 200mg/kg/10D- (200mg/kg) gastrointestinal: other changes Southern Medical Journal. Vol. 77, Pg. 532, 1984.

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