66085-59-4|NimodipineProducts Supply - Chemical intermediates Network

Nimodipine cas no:66085-59-4

Synonyms: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethylester (9CI);Admon;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl)5-(1-methylethyl) ester;Nimodipine AP;Nimotop;Periplum;

Identification

NameNimodipine
CAS66085-59-4
Synonyms3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethylester (9CI);Admon;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl)5-(1-methylethyl) ester;Nimodipine AP;Nimotop;Periplum;
EINECS(EC#)266-127-0
Molecular FormulaC₂₁H₂₆N₂O₇
Molecular Weight418.44034

Chemical Properties

Appearanceyellow crystalline powder
refractive index1.561
storage tempStore in a tightly closed container. Store in a dry area.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Hazard Xn:Harmful
Risk R20/21/22
Safety

Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes:? Harmful Xn
Risk Statements: 20/21/22?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36?
S36: Wear suitable protective clothing.
WGK Germany: 1
RTECS of Nimodipine (CAS NO.66085-59-4): US7975500

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	4mg/kg (4mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986.
dog	LD50	oral	1gm/kg (1000mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.
mouse	LD50	intravenous	26200ug/kg (26.2mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.
mouse	LD50	oral	940mg/kg (940mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.
mouse	LD50	subcutaneous	9500mg/kg (9500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.
rabbit	LD50	intravenous	2500ug/kg (2.5mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986.
rabbit	LD50	oral	5gm/kg (5000mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1733, 1986.
rat	LD50	intravenous	5mg/kg (5mg/kg)	?	Archives of Toxicology. Vol. 54, Pg. 275, 1983.
rat	LD50	oral	2738mg/kg (2738mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.
rat	LD50	subcutaneous	4234mg/kg (4234mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 6899, 1985.

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Nimodipine cas no:66085-59-4

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