Benzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl- cas no:664-95-9

NameBenzenesulfonamide,N-[(cyclohexylamino)carbonyl]-4-methyl-
CAS664-95-9
SynonymsUrea,1-cyclohexyl-3-(p-tolylsulfonyl)- (8CI); 1-(p-Tolylsulfonyl)-3-cyclohexylurea;1-Cyclohexyl-3-p-tolylsulfonylurea; Agliral; Cicloral; Cychloral; Cyclamid;Cyclamide; Cyclamide (Russian); Diaboral; Gliciclamide; Glycyclamid;Glycyclamide; K 386; N-(4-Tolylsulfonyl)-N'-cyclohexylurea;N-Cyclohexyl-N'-(p-tolylsulfonyl)urea; NSC 142661; Tolcyclamide; Tolhexamide;Tsiklamid
EINECS(EC#)211-557-6
Molecular FormulaC14H20 N2 O3 S
Molecular Weight296.42

refractive index1.578

Safety Moderately toxic by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx and NOx.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

YS7800000

CHEMICAL NAME :

Urea, 1-cyclohexyl-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :

664-95-9

BEILSTEIN REFERENCE NO. :

1995860

LAST UPDATED :

199706

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C14-H20-N2-O3-S

MOLECULAR WEIGHT :

296.42

WISWESSER LINE NOTATION :

L6TJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

870 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,268,1957

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1150 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

800 mg/kg

SEX/DURATION :

female 9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,616,1965