Nitrofurantoin cas no:67-20-9
Synonyms: Furadonin;Uerineks;Sodium nitrofurantoin;Berkfuran;Macrodantina;1-[[(5-Nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione;Urantoin;2,4-Imidazolidinedione,1-[[(5-nitro-2- furanyl)methylene]amino]-;1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione;Urolisa;Furatoin;NSC-2107;Furadantin;N-Toin;1-(5-Nitro-2-furfurylidenamino)hydantoin;54-87-5;5-Nitrofurantoin;Furadonine;2,4-Imidazolidinedione, 1-[[ (5-nitro-2-furanyl)methylene]amino]-;Macrofurin;Trantoin;Urodin;Furina;Hydantoin, 1-(5-nitro-furfurylideneamino)-;Macpac;Hydantoin, 1-((5-nitrofurfurylidene)amino)-;Zoofurin;PiyEloseptyl;Ceduran;Urofuran;Welfurin;N-(5-Nitrofurfurylidene)-1-aminohydantoin;ND-7248;Furadontin;Furadantin Retard;Urolong;Furadantin (TN);Cistofuran;Furadantine mc;Nifurantin;Siraliden;Urofurin;Nitrofuradantin;Alfuran;Furophen T;Parfuran;Macrobid;Ro-Antoin;Nitoin;Benkfuran;2,4-Imidazolidenedione, 1-(((5-nitro-2-furanyl)methylene)amino)-;Chemiofuran;
NameNitrofurantoin
CAS67-20-9
SynonymsFuradonin;Uerineks;Sodium nitrofurantoin;Berkfuran;Macrodantina;1-[[(5-Nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione;Urantoin;2,4-Imidazolidinedione,1-[[(5-nitro-2- furanyl)methylene]amino]-;1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione;Urolisa;Furatoin;NSC-2107;Furadantin;N-Toin;1-(5-Nitro-2-furfurylidenamino)hydantoin;54-87-5;5-Nitrofurantoin;Furadonine;2,4-Imidazolidinedione, 1-[[ (5-nitro-2-furanyl)methylene]amino]-;Macrofurin;Trantoin;Urodin;Furina;Hydantoin, 1-(5-nitro-furfurylideneamino)-;Macpac;Hydantoin, 1-((5-nitrofurfurylidene)amino)-;Zoofurin;PiyEloseptyl;Ceduran;Urofuran;Welfurin;N-(5-Nitrofurfurylidene)-1-aminohydantoin;ND-7248;Furadontin;Furadantin Retard;Urolong;Furadantin (TN);Cistofuran;Furadantine mc;Nifurantin;Siraliden;Urofurin;Nitrofuradantin;Alfuran;Furophen T;Parfuran;Macrobid;Ro-Antoin;Nitoin;Benkfuran;2,4-Imidazolidenedione, 1-(((5-nitro-2-furanyl)methylene)amino)-;Chemiofuran;
EINECS(EC#)200-646-5
Molecular FormulaC8H6N4O5
Molecular Weight238.16
Appearancelemon yellow crystalline powder
refractive index1.52 (20 C)
storage temp0-6°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn:Harmful;
Risk R22;R42/43
Safety Hazard Codes:Xn
Risk Statements:22-42/43
22:Harmful if swallowed
42/43:May cause sensitization by inhalation and skin contact
Safety Statements:22-36/37-45
22:Do not breathe dust
36/37:Wear suitable protective clothing and gloves
45:In case of accident or if you feel unwell, seek medical
advice immediately (show label where possible)
RIDADR:2811
WGK Germany:3
HazardClass:6.1(b)
PackingGroup:III
HS Code:29349990
HS Code 29349990
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MU2800000
- CHEMICAL NAME :
- Hydantoin, 1-((5-nitrofurfurylidene)amino)-
- CAS REGISTRY NUMBER :
- 67-20-9
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 79
- MOLECULAR FORMULA :
- C8-H6-N4-O5
- MOLECULAR WEIGHT :
- 238.18
- WISWESSER LINE NOTATION :
- T5OJ BNW E1UN- AT5NVMV EHJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 40 mg/kg/2W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - proteinuria
Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - recording from peripheral motor nerve
Behavioral - ataxia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 29 mg/kg/20D-I
- TOXIC EFFECTS :
- Brain and Coverings - increased intracranial pressure
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Blood - other hemolysis with or without anemia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 42 mg/kg/6W-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse
Liver - jaundice, other or unclassified
Liver - liver function tests impaired
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 604 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 360 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 mg/kg/14D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45500 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 gm/kg/14D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3276 mg/kg/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10815 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21630 mg/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - ovarian tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 140 mg/kg
- SEX/DURATION :
- male 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2100 mg/kg
- SEX/DURATION :
- male 14 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - other effects on male
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1740 mg/kg
- SEX/DURATION :
- male 8 week(s) pre-mating
female 2 week(s) pre-mating - 2 week(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1920 mg/kg
- SEX/DURATION :
- male 8 week(s) pre-mating
female 2 week(s) pre-mating - 3 week(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 105 gm/kg
- SEX/DURATION :
- female 43 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 87500 ug/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 75 mg/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 750 mg/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
- TYPE OF TEST :
- Specific locus test
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Sperm Morphology
- TYPE OF TEST :
- DNA damage
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 200 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 225,181,1989
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,211,1990
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,211,1990
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 50,211,1990
TOXICOLOGY REVIEW
CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of
the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year:
4,171,1978
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
2,365,1973
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 25,270,1967
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NOES Hazard Code - 84411
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No. of Employees: 3756 (estimated)
No. of Female Employees: 2239 (estimated)