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Isopropanol cas no:67-63-0

Synonyms: 2-propanol absolute over molecular sieve (H2O <0.005%); IPA; Isopropylalcohol,99.5%; isopropanol anhydrous; 2-PROPANOL ULTRA RESI-ANALYZED; isopropanol molecular biology; Isopropanol~Isopropyl alcohol; Isopropyl Alcohol; Isopropanol 70%; Propan-2-ol - SPECIFIED; 2-Propanol; iso propyl alcohol

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Identification
NameIsopropanol
CAS67-63-0
Synonyms2-propanol absolute over molecular sieve (H2O <0.005%); IPA; Isopropylalcohol,99.5%; isopropanol anhydrous; 2-PROPANOL ULTRA RESI-ANALYZED; isopropanol molecular biology; Isopropanol~Isopropyl alcohol; Isopropyl Alcohol; Isopropanol 70%; Propan-2-ol - SPECIFIED; 2-Propanol; iso propyl alcohol
EINECS(EC#)200-661-7
Molecular FormulaC3H8O
Molecular Weight60.09
Chemical Properties
AppearanceColourless liquid
refractive index1.376-1.378
storage tempFlammables area
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard F:Flammable
Risk 11-36-67-40-10-36/38
Safety

Hazard Codes:,IrritantXi FlammableF,HarmfulXn
Risk Statements: 11-36-67-40-10-36/38
R11:Highly flammable.
R36:Irritating to eyes.
R67:Vapours may cause drowsiness and dizziness.
R40:Limited evidence of a carcinogenic effect.
R10:Flammable.
R36/38:Irritating to eyes and skin.
Safety Statements: 7-16-24/25-26-36/37
S7:Keep container tightly closed.
S16:Keep away from sources of ignition.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
RIDADR: UN 1219 3/PG 2


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1963mg/kg (1963mg/kg) ? "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955.
cat LDLo oral 6mL/kg (6mL/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 26, Pg. 285, 1921.
dog LDLo intravenous 1024mg/kg (1024mg/kg) ? Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944.
dog LDLo oral 1537mg/kg (1537mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 561, 1944.
frog LDLo parenteral 20gm/kg (20000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935.
guinea pig LD50 intraperitoneal 2560mg/kg (2560mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
hamster LD50 intraperitoneal 3444mg/kg (3444mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
human LDLo oral 3570mg/kg (3570mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: NAUSEA OR VOMITING		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 339, 1969.
human LDLo unreported 2mL/kg (2mL/kg) ? Japanese Journal of Toxicology. Vol. 12, Pg. 341, 1999.
human TDLo oral 223mg/kg (223mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Laboratory and Clinical Medicine. Vol. 12, Pg. 326, 1927.
infant TDLo oral 13gm/kg (13000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: IRRITABILITY

GASTROINTESTINAL: NAUSEA OR VOMITING		 American Journal of Emergency Medicine. Vol. 10, Pg. 542, 1992.
?
infant TDLo unreported 1375mg/kg (1375mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Pediatric Emergency Care. Vol. 9, Pg. 146, 1993.
?
mammal (species unspecified) LDLo subcutaneous 6gm/kg (6000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC		 Archiv fuer Toxikologie. Vol. 16, Pg. 84, 1956.
man LDLo oral 5272mg/kg (5272mg/kg) BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA		 American Journal of Clinical Pathology. Vol. 38, Pg. 144, 1962.
?
man LDLo unreported 2770mg/kg (2770mg/kg) ? "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 14432mg/kg (14432mg/kg) BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 New England Journal of Medicine. Vol. 277, Pg. 699, 1967.
?
mouse LCLo inhalation 12800ppm/3H (12800ppm) ? Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LD50 intraperitoneal 4477mg/kg (4477mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
mouse LD50 intravenous 1509mg/kg (1509mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
mouse LD50 oral 3600mg/kg (3600mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978.
mouse LDLo subcutaneous 6gm/kg (6000mg/kg) ? "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 172, 1955.
rabbit LD50 intraperitoneal 667mg/kg (667mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
rabbit LD50 intravenous 1184mg/kg (1184mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
rabbit LD50 oral 6410mg/kg (6410mg/kg) ? FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 114, 1970.
rabbit LD50 skin 12800mg/kg (12800mg/kg) ? Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974.
rat LC50 inhalation 16000ppm/8H (16000ppm) ? Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 100, 1974.
rat LD50 intraperitoneal 2735mg/kg (2735mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
rat LD50 intravenous 1088mg/kg (1088mg/kg) ? EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985.
?
rat LD50 oral 5045mg/kg (5045mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(1), Pg. 8, 1978.

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