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Eflornithine cas no:67037-37-0

Synonyms: DL-ALPHA-DIFLUOROMETHYLORNITHINE ; DIFLUOROMETHYLORNITHINE ; EFLORNITINE ; DFMO ; H-DL-(F2ME)ORN-OH ; H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH ; H-ALPHA-DIFLUORO-ME-DL-ORN-OH ; ALPHA-DIFLUOROMETHYL-DL-ORNITHINE ; ALPHA-DIFLUORO-ME-DL-ORNITHINE ; D,L-2-DIFLUOROMETHYLORNITHINE ; H-DL-(A-DIFLUOROMETHYL)ORN-OH ; Eflornithine base

Identification
NameEflornithine
CAS67037-37-0
SynonymsDL-ALPHA-DIFLUOROMETHYLORNITHINE ; DIFLUOROMETHYLORNITHINE ; EFLORNITINE ; DFMO ; H-DL-(F2ME)ORN-OH ; H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH ; H-ALPHA-DIFLUORO-ME-DL-ORN-OH ; ALPHA-DIFLUOROMETHYL-DL-ORNITHINE ; ALPHA-DIFLUORO-ME-DL-ORNITHINE ; D,L-2-DIFLUOROMETHYLORNITHINE ; H-DL-(A-DIFLUOROMETHYL)ORN-OH ; Eflornithine base
Molecular FormulaC6H12F2N2O2
Molecular Weight182.17
Chemical Properties
refractive index1.462
storage temp-15°C
Safety Data

Safety

Poison by intracerebral route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of F and NOx. An ornithine-decarboxylase inhibitor.


Toxicity
1.    

msc-hmn:lym 1250 µmol/L

    CNREA8    Cancer Research. 44 (1984),4272.
2.    

cyt-ham:ovr 500 µmol/L

    CNREA8    Cancer Research. 44 (1984),4535.
3.    

ice-rat LD50:1364 µg/kg

    APTOA6    Acta Pharmacologica et Toxicologica. 56 (1985),250.

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