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Hazard Severe explosion risk.
Risk 11-20/21/22-36/37/38
Safety
Poison by intraperitoneal route. Many N-nitroso compounds are carcinogens. An explosive. Dangerous when stored in sealed containers as it decomposes to release nitrogen. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and EXPLOSIVES, HIGH.
Safety Information of Nitrosoguanidine (CAS NO.674-81-7):
Risk Statements: 11-20/21/22-36/37/38
11: Highly Flammable
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 16-26-36/37/39
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
RIDADR: 1325
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD | oral | > 5gm/kg (5000mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 563, 1993. | |
| mouse | LDLo | intraperitoneal | 21mg/kg (21mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972. | |
| rabbit | LD | skin | > 2gm/kg (2000mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 563, 1993. | |
| rat | LD | oral | > 5gm/kg (5000mg/kg) | BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 563, 1993. |
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