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Aminopyrine sodium sulfonate cas no:68-89-3

Synonyms: Dipyrone(6CI);Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt (8CI);ARPF;Optalgin;Pyralgine;Pyretin;Sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate;Sodium noramidopyrine methanesulfonate;Sulpin;Sulpyrine;Algopyrin;Anador;Analgin;Andolor;Conmel;Diprofarn;Metamizol;Metamizole sodium;Metamizole sodium salt;Methamizole sodium;Metilon;Neo-melubrine;Noramidopyrine methanesulfonatesodium;Noraminophenazone sodium mesylate;Novalgetol;Novamidazophen;Novaminsulfone;Novaminsulfonium;Noveltex;

Identification
NameAminopyrine sodium sulfonate
CAS68-89-3
SynonymsDipyrone(6CI);Methanesulfonic acid, (antipyrinylmethylamino)-, sodium salt (8CI);ARPF;Optalgin;Pyralgine;Pyretin;Sodium1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate;Sodium noramidopyrine methanesulfonate;Sulpin;Sulpyrine;Algopyrin;Anador;Analgin;Andolor;Conmel;Diprofarn;Metamizol;Metamizole sodium;Metamizole sodium salt;Methamizole sodium;Metilon;Neo-melubrine;Noramidopyrine methanesulfonatesodium;Noraminophenazone sodium mesylate;Novalgetol;Novamidazophen;Novaminsulfone;Novaminsulfonium;Noveltex;
EINECS(EC#)200-694-7
Molecular FormulaC13H16N3NaO4S
Molecular Weight333.33861
Chemical Properties
AppearanceWhite or yellowish crystalline powder, odorless, tiny bitter
storage temp2-8°C
Safety Data

Hazard Xn: Harmful;
Risk R42/43
Safety

Hazard Codes?of Aminopyrine sodium sulfonate (CAS NO.68-89-3):?HarmfulXn
Risk Statements: 42/43?
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 36?
S36: Wear suitable protective clothing.
WGK Germany: 2
RTECS: PB1300000
Poison by subcutaneous route. Moderately toxic by several other routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. See also SULFONATES.?When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo subcutaneous 3gm/kg (3000mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
mouse LC50 inhalation 37200mg/m3 (37200mg/m3) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(10), Pg. 36, 1969.
mouse LD50 intraperitoneal 250mg/kg (250mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 107, Pg. 322, 1956.
mouse LD50 intravenous 2197mg/kg (2197mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974.
mouse LD50 oral 2891mg/kg (2891mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974.
mouse LD50 subcutaneous 69mg/kg (69mg/kg) ? Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968.
mouse LD50 unreported 2750mg/kg (2750mg/kg) ? Journal of Drug Research. Vol. 4, Pg. 89, 1972.
rabbit LD50 oral 2150mg/kg (2150mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979.
rabbit LDLo subcutaneous 3gm/kg (3000mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.
rat LC inhalation > 900mg/m3 (900mg/m3) ? Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 47, 1979.
rat LD50 intramuscular 1625mg/kg (1625mg/kg) ? Russian Pharmacology and Toxicology Vol. 51, Pg. 183, 1988.
rat LD50 intraperitoneal 2470mg/kg (2470mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 478, 1977.
rat LD50 intravenous 2182mg/kg (2182mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 703, 1976.
rat LD50 oral 3gm/kg (3000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971.
rat LD50 subcutaneous 2117mg/kg (2117mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 600, 1974.

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