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Hexamethylphosphoramide cas no:680-31-9

Synonyms: HEMPA; Hexametapol; Hexamethylphosphoric triamide; HMPT; Phosphoric acid hexamethyltriamide; HMPA; Hexamethyl Phosphoramide

Identification
NameHexamethylphosphoramide
CAS680-31-9
SynonymsHEMPA; Hexametapol; Hexamethylphosphoric triamide; HMPT; Phosphoric acid hexamethyltriamide; HMPA; Hexamethyl Phosphoramide
EINECS(EC#)211-653-8
Molecular FormulaC6H18N3OP
Molecular Weight179.2
Chemical Properties
Appearanceclear colorless to light amber liquid
refractive index1.459
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T:Toxic;
Risk R45;R46
Safety

Hazard Codes: ToxicT
Risk Statements: 45-46 
R45:May cause cancer. 
R46:May cause heritable genetic damage.
Safety Statements: 53-45-9 
S53:Avoid exposure - obtain special instructions before use. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S9:Keep container in a well-ventilated place.
RIDADR: 2810
WGK Germany: 3
RTECS: TD0875000
F: 8
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 680-31-9(Hazardous Substances Data)
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion, skin contact, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of phosphine, POx, and NOx.


Toxicity
1.    

dns-hmn:hla 125 mg/L

    PMRSDJ    Progress in Mutation Research. 5 (1985),375.
2.    

cyt-hmn:lym 500 mg/L

    MUREAV    Mutation Research. 156 (1985),19.
3.    

sce-rat:lvr 2 g/L

    PMRSDJ    Progress in Mutation Research. 5 (1985),287.
4.    

ihl-rat TCLo:50 ppb/52W-C:CAR

    AJPAA4    American Journal of Pathology. 106 (1982),8.
5.    

orl-rat LD50:2650 mg/kg

    NATUAS    Nature. 211 (1966),146.
6.    

skn-rat LDLo:3500 mg/kg

    NATUAS    Nature. 211 (1966),146.
7.    

orl-mus LD50:2400 mg/kg

    NYKZAU    Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 70 (1974),114P.
8.    

ipr-mus LD50:1600 mg/kg

    PMRSDJ    Progress in Mutation Research. 1 (1981),682.
9.    

ivn-mus LD50:800 mg/kg

    CHINAG    Chemistry and Industry.(36),(1966),1529.
10.    

orl-rbt LDLo:1500 mg/kg

    JEENAI    Journal of Economic Entomology. 48 (1955),139.
11.    

skn-rbt LD50:2600 mg/kg

   

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