Tetramethyl orthosilicate cas no:681-84-5

NameTetramethyl orthosilicate
CAS681-84-5
SynonymsTetramethoxysilanecolorlessliq; Methyl silicate; DYNASIL M; Tetramethoxysilane; Silicon tetramethoxide
EINECS(EC#)211-656-4
Molecular FormulaC4H12O4Si
Molecular Weight152.22

Appearancecolourless liquid
refractive index1.367-1.37
storage tempFlammables area
Sensitive Moisture Sensitive

Hazardclass6.1

Hazard T+:Verytoxic;
Risk R10;R26;R37/38;R41
Safety

Poison by intraperitoneal route. Moderately toxic by inhalation. Mildly toxic by skin contact. A severe eye irritant. This material can cause extensive necrosis (experimentally), keratoconus, and opaque cornea. It also causes severe human eye injuries, as well as necrosis of corneal cells, which progresses long after exposure has ceased. It is destructive and its effects resist treatment. Permanent blindness is possible from exposure to it. The kidney seems to be most subject to injury regardless of the mode of exposure. Pulmonary edema has also occurred. This material is more toxic than either ethyl silicate or silicic acid, although it has been thought that the injury caused is largely due to the action of the silicic acid. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. Potentially violent reaction with metal hexafluorides (e.g., rhenium, molybdenum, tungsten). When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:?T+
Risk Statements: 10-26-37/38-41?
R10:Flammable.?
R26:Very toxic by inhalation.?
R37/38:Irritating to respiratory system and skin.?
R41:Risk of serious damage to the eyes.
Safety Statements: 16-26-36/37/39-45-28A?
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2606 6.1/PG 1
WGK Germany: 3
RTECS: VV9800000
F: 10-21
TSCA: Yes
HazardClass: 6.1
PackingGroup: I

HS Code 29209085

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	1gm/kg (1000mg/kg)	?	Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse	LCLo	inhalation	1gm/m3/10M (1000mg/m3)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE MUSCULOSKELETAL: OTHER CHANGES	National Defense Research Committee, Office of Scientific Research and Development, Progress Report.Vol. NDCrc-132, Pg. MAY1942,
mouse	LD50	intraperitoneal	250mg/kg (250mg/kg)	?	"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 2, Pg. 56, 1950.
rabbit	LD50	skin	17mL/kg (17mL/kg)	?	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rabbit	LDLo	intravenous	100mg/kg (100mg/kg)	LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	"Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980Vol. 3, Pg. 935, 1968.
rat	LCLo	inhalation	250ppm/4H (250ppm)	?	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
rat	LD50	intraperitoneal	100mg/kg (100mg/kg)	?	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1222, 1986.
rat	LDLo	oral	700mg/kg (700mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	"Dangerous Properties of Industrial Materials," Sax, N.I., New York, Van Nostrand Reinhold, 1980Vol. 3, Pg. 935, 1968.