68844-77-9|AstemizoleProducts Supply - Chemical intermediates Network

Astemizole cas no:68844-77-9

Synonyms: Astemisan;Hismanal;Histamen;Histaminos;Histazol;Kelp;Laridal;Metodik;NSC 329963;Novo-Nastizol A;Paralergin;R 43512;Retolen;Waruzol;

Identification

NameAstemizole
CAS68844-77-9
SynonymsAstemisan;Hismanal;Histamen;Histaminos;Histazol;Kelp;Laridal;Metodik;NSC 329963;Novo-Nastizol A;Paralergin;R 43512;Retolen;Waruzol;
EINECS(EC#)272-441-9
Molecular FormulaC₂₈H₃₁FN₄O
Molecular Weight458.63

Chemical Properties

AppearanceWhite powder
refractive index1.623
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Data

Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: arrhythmias, coma, nausea or vomiting, somnolence. When heated to decomposition it emits toxic fumes of F^? and NO_x.
Hazard Codes:? Harmful Xn
Risk Statements: 22-36/37/38?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DD8968000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	21800ug/kg (21.8mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
dog	LD50	oral	> 320mg/kg (320mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
guinea pig	LD50	oral	933mg/kg (933mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
infant	TDLo	oral	3500ug/kg (3.5mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Pediatric Emergency Care. Vol. 12, Pg. 102, 1996.
mouse	LD50	intravenous	35mg/kg (35mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse	LD50	oral	2560mg/kg (2560mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
mouse	LD50	subcutaneous	1928mg/kg (1928mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat	LD50	intravenous	28200ug/kg (28.2mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
rat	LD50	oral	> 2560mg/kg (2560mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
rat	LD50	subcutaneous	355mg/kg (355mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
women	TDLo	oral	1200ug/kg (1.2mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Pediatric Emergency Care. Vol. 12, Pg. 102, 1996.
women	TDLo	oral	4mg/kg (4mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Human Toxicology. Vol. 5, Pg. 43, 1986.
women	TDLo	oral	4mg/kg (4mg/kg)	BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 292, Pg. 660, 1986.
women	TDLo	oral	4mg/kg (4mg/kg)	CARDIAC: CHANGE IN RATE	Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 121, 1993.
women	TDLo	oral	5400ug/kg (5.4mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Pediatric Emergency Care. Vol. 9, Pg. 23, 1993.

supplier list

HEBEI CUI FENG IMPORT&EXPORT TRADE CO.,LTD: Tel:86-311-80955068; Address: No 98 Gongnong Street,Shijiazhuang Hebei,China

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road Shirley, NY 11967, USA

Jinan Haohua Industry Co., Ltd.: Tel:0086-531-58773055; Address: No.59 Gongye South RD

ORCHID CHEMICAL SUPPLIES LTD (OCS): Tel:+86-571-85395792; Address: 607, North Zhongshan Road, Hangzhou 310000 China

NANTONG CHEM-TECH.(GROUP) CO.,LTD: Tel:0086-513-85081108 85335860; Address: 7/F Beihao BLDG, No. 91,Zhongxiu Middle Road, Nantong,China

HangZhou Peak Chemical Co.,Ltd: Tel:+86-571-88233073; Address: Rm. 3-502,Building 3 Tucuiyuan,Lakeside Garden,No.176 Wenyi West Road, HangZhou,China

Andard-Mount Company Ltd.: Tel:+44-(20)-89915150; Address: 20, Hanover Square, London W1S 1JY,

Laiwu Hehui Chemical Co.,Ltd.: Tel:+86-(531)-88772589; Address: Huashan Rd., Jinan City, Shandong 250000,

Haihang Industry Co., Ltd.: Tel:+86-(531)-88032799; Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100,

Hangzhou Sage Chemical Co., Ltd.: Tel:86-571-86818502; Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Santa Cruz Biotechnology, Inc.: Tel:+1-(831)-457-3800; Address: 2145, Delaware Avenue, Santa Cruz, California 95060,

Fischer Chemicals AG: Tel:+41-44-389 69 69; Address: Riesbachstrasse 57 8034 Zurich, Switzerland

Moravek Biochemicals Inc.: Tel:+1-714-990-2018; Address: 577 Mercury Lane Brea, CA 92821 U.S.A.

LGC Promochem: Tel:+44 (0)20 8943 8480; Address: Queens Rd TEDDINGTON Middlesex TW11 0LY United Kingdom

Astemizole cas no:68844-77-9

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