68844-77-9|AstemizoleProducts Supply - Chemical intermediates Network

Astemizole cas no:68844-77-9

Synonyms: Astemisan;Hismanal;Histamen;Histaminos;Histazol;Kelp;Laridal;Metodik;NSC 329963;Novo-Nastizol A;Paralergin;R 43512;Retolen;Waruzol;

Identification

NameAstemizole
CAS68844-77-9
SynonymsAstemisan;Hismanal;Histamen;Histaminos;Histazol;Kelp;Laridal;Metodik;NSC 329963;Novo-Nastizol A;Paralergin;R 43512;Retolen;Waruzol;
EINECS(EC#)272-441-9
Molecular FormulaC₂₈H₃₁FN₄O
Molecular Weight458.63

Chemical Properties

AppearanceWhite powder
refractive index1.623
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Data

Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: arrhythmias, coma, nausea or vomiting, somnolence. When heated to decomposition it emits toxic fumes of F^? and NO_x.
Hazard Codes:? Harmful Xn
Risk Statements: 22-36/37/38?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DD8968000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	21800ug/kg (21.8mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
dog	LD50	oral	> 320mg/kg (320mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
guinea pig	LD50	oral	933mg/kg (933mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
infant	TDLo	oral	3500ug/kg (3.5mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Pediatric Emergency Care. Vol. 12, Pg. 102, 1996.
mouse	LD50	intravenous	35mg/kg (35mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
mouse	LD50	oral	2560mg/kg (2560mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
mouse	LD50	subcutaneous	1928mg/kg (1928mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 239, 1995.
rat	LD50	intravenous	28200ug/kg (28.2mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
rat	LD50	oral	> 2560mg/kg (2560mg/kg)	?	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 251, Pg. 39, 1981.
rat	LD50	subcutaneous	355mg/kg (355mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 381, 1983.
women	TDLo	oral	1200ug/kg (1.2mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Pediatric Emergency Care. Vol. 12, Pg. 102, 1996.
women	TDLo	oral	4mg/kg (4mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Human Toxicology. Vol. 5, Pg. 43, 1986.
women	TDLo	oral	4mg/kg (4mg/kg)	BEHAVIORAL: COMA CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 292, Pg. 660, 1986.
women	TDLo	oral	4mg/kg (4mg/kg)	CARDIAC: CHANGE IN RATE	Journal of Toxicology, Clinical Toxicology. Vol. 31, Pg. 121, 1993.
women	TDLo	oral	5400ug/kg (5.4mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP	Pediatric Emergency Care. Vol. 9, Pg. 23, 1993.

supplier list

THYKN (INDIA) INTERNATIONAL: Tel:+91-22-67033666 (3 lines); Address: 202, Kuntal, Mody Estate, Nr.Pipeline, LBS Road, Ghatkopar (West), Mumbai - 400086, India

Fine Chem Trading LTD: Tel:+44-079-7062-7591; Address: PO Box 292, Greenford, UB6 9ZL, England

Apex Drug House: Tel:+91-22-22077266; Address: 28, Mahendra Mansion, Babu Genu Road,Mumbai-400 002.

Aurobindo Pharma Ltd.: Tel:+91-40- 5572 5000; Address: Plot # 2, Maitri Vihar, Ameerpet,Hyderabad ?500 038,Andhra Pradesh, India

S&D Chemicals (Canada) Ltd.: Tel:+1-416-299-7772; Address: 131 Finchdene Square, Unit 7 Scarborough, Ontario M1X 1A6

LGC Promochem: Tel:+44 (0)20 8943 8480; Address: Queens Rd TEDDINGTON Middlesex TW11 0LY United Kingdom

Moravek Biochemicals Inc.: Tel:+1-714-990-2018; Address: 577 Mercury Lane Brea, CA 92821 U.S.A.

Fischer Chemicals AG: Tel:+41-44-389 69 69; Address: Riesbachstrasse 57 8034 Zurich, Switzerland

Phaarmasia Ltd.: Tel:+91-(40)-3095002; Address: 16,Phase III, I.D.A Jeedimetla, Hyderabad, Andhra Pradesh 500 055,

Sol Pharmaceuticals Ltd.: Tel:+91-(40)-2235542; Address: Saphire Building, 5-9-88/2, Fateh Maidan, Hyderabad, Andhra Pradesh 500 001,

Standard Organics Ltd.: Tel:+91-(40)-3237366; Address: 5-9-8812 Saphire bldg., Fateh Maidan, Hyderabad, Andhra Pradesh 500001,

Trident Organics (P) Ltd.: Tel:+91-(40)-2223716; Address: 7-1-27 Ameerpet., Hyderabad, Andhra Pradesh 500016,

Sudharsan Laboratories Limited.: Tel:+91-(40)-23544795, 23544885; Address: Plot No.1072, Road No.44, Jubilee Hills, Hyderabad, Andhra Pradesh 500 033,

Anglo - French Drugs & Industries Ltd.: Tel:+91-(80)-3356757; Address: 41, 3rd Cross, 5th Block, SSI Area Rajajinagar, Bangalore, Karnataka 560010,

S.S.T. Corporation: Tel:+1-(973)-473-4300; Address: 635 Brighton Road, Clifton, New Jersey 07012,

Astemizole cas no:68844-77-9

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