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Ampicillin cas no:69-53-4

Synonyms: (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-Thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-[2alpha, 5alpha, 6beta(S*)]]-; 6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid; 6-[D(-)-alpha-aminophenylacetamido]penicillanic acid; Adobacillin; Alpen; Amblosin; Amfipen; amino]-3,3,-dimethyl-7-oxo-4-thia-1-azabicyclo; Aminobenzylpenicillin; Amipenix; Amipenix S; Ampi-Bol; Ampicillin; Ampicillin A; Ampicillin Sulbactam; Ampicin; Ampicina; Ampicyn; Ampilar; Ampimed; Ampipenin; Ampi-Tablinen; Amplisom; Amplital; Ampy-Penyl; Austrapen; Binotal; Bonapicillin; Britacil; Copharcilin; D(-)-alpha-aminobenzylpenicillin; D(-)-aplha-aminobenzylpenicillin; Doktacillin; Grampenil; Guicitrina; Marisilan; Nuvapen; Omnipen; Pen-Bristol; Penbritin; Penbrock; Penicline; Penstabil; Pentrex; Pentrexyl; Polycillin; Ponecil; QI Damp; Rosampline; Synpenin; Tokiocillin; Totacillin; Totalciclina; Totapen; Ultrabion; Unasyn; Viccillin; Wymox;

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Identification
NameAmpicillin
CAS69-53-4
Synonyms(2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-Thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-[2alpha, 5alpha, 6beta(S*)]]-; 6-[(Aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid; 6-[D(-)-alpha-aminophenylacetamido]penicillanic acid; Adobacillin; Alpen; Amblosin; Amfipen; amino]-3,3,-dimethyl-7-oxo-4-thia-1-azabicyclo; Aminobenzylpenicillin; Amipenix; Amipenix S; Ampi-Bol; Ampicillin; Ampicillin A; Ampicillin Sulbactam; Ampicin; Ampicina; Ampicyn; Ampilar; Ampimed; Ampipenin; Ampi-Tablinen; Amplisom; Amplital; Ampy-Penyl; Austrapen; Binotal; Bonapicillin; Britacil; Copharcilin; D(-)-alpha-aminobenzylpenicillin; D(-)-aplha-aminobenzylpenicillin; Doktacillin; Grampenil; Guicitrina; Marisilan; Nuvapen; Omnipen; Pen-Bristol; Penbritin; Penbrock; Penicline; Penstabil; Pentrex; Pentrexyl; Polycillin; Ponecil; QI Damp; Rosampline; Synpenin; Tokiocillin; Totacillin; Totalciclina; Totapen; Ultrabion; Unasyn; Viccillin; Wymox;
EINECS(EC#)200-709-7
Molecular FormulaC16H19N3O4S
Molecular Weight349.4
Chemical Properties
AppearanceCrystalline Solid
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass8
Safety Data

Hazard Xn:Harmful
Risk R36/37/38;R42/43
Safety Poison by intracerebral route. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: fever, agranulocytosis, and other blood effects. An experimental teratogen. Mutation data reported. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Hazard Codes:Xn
Risk Statements: 36/37/38-42/43
S36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.

HS Code 29212900

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous > 100mg/kg (100mg/kg) ? British Medical Journal. Vol. 2, Pg. 197, 1961.
guinea pig LD50 unreported 7500ug/kg (7.5mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
man TDLo oral 400mg/kg/4W-I (400mg/kg) BLOOD: AGRANULOCYTOSIS
BLOOD: OTHER CHANGES		 Annals of Internal Medicine. Vol. 69, Pg. 91, 1968.
mouse LD50 intracrebral 380mg/kg (380mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: EXCITEMENT
MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES		 Chemotherapy Vol. 26, Pg. 196, 1980.
mouse LD50 intraperitoneal 3250mg/kg (3250mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 9, Pg. 83, 1980.
mouse LD50 intravenous 4600mg/kg (4600mg/kg) ? Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 987, 1977.
mouse LD50 oral > 5gm/kg (5000mg/kg) ? Drugs in Japan Vol. 6, Pg. 57, 1982.
mouse LD50 parenteral > 3gm/kg (3000mg/kg) ? Drugs in Japan Vol. -, Pg. 114, 1995.
mouse LD50 unreported 28gm/kg (28000mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
mouse LDLo subcutaneous > 5gm/kg (5000mg/kg) ? British Medical Journal. Vol. 2, Pg. 197, 1961.
rat LD50 intraperitoneal 4500mg/kg (4500mg/kg) ? Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 intravenous 6200mg/kg (6200mg/kg) ? Drugs in Japan Vol. -, Pg. 88, 1990.
rat LD50 parenteral > 3gm/kg (3000mg/kg) ? Drugs in Japan Vol. -, Pg. 114, 1995.
rat LD50 unreported 10gm/kg (10000mg/kg) ? Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 42(9), Pg. 10, 1977.
rat LDLo oral > 5gm/kg (5000mg/kg) ? British Medical Journal. Vol. 2, Pg. 197, 1961.
rat LDLo subcutaneous > 5gm/kg (5000mg/kg) ? British Medical Journal. Vol. 2, Pg. 197, 1961.
women TDLo oral 160mg/kg/4D-I (160mg/kg) BLOOD: AGRANULOCYTOSIS

BLOOD: THROMBOCYTOPENIA		 Annals of Internal Medicine. Vol. 99, Pg. 573, 1983.

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