D-Mannitol cas no:69-65-8
Synonyms: Resectisol;Osmitrol (TN);Mannistol;(2S,3S,4R,5R)-hexane-1,2,3,4,5,6-hexol;Mannitol, D-;Mannite;D(-)-Mannitol;Mannidex;Manna sugar;Maniton-S;Diosmol;Mannitol (USP);1,2,3,4,5,6-Hexanehexol;Osmosal;Cordycepic acid;NCI-C50362;Mannit;Mannazucker;Isotol;D-Mannit;Mannitol, Powder;Spray-dried mannitol;D-(-)-Mannitol;
NameD-Mannitol
CAS69-65-8
SynonymsResectisol;Osmitrol (TN);Mannistol;(2S,3S,4R,5R)-hexane-1,2,3,4,5,6-hexol;Mannitol, D-;Mannite;D(-)-Mannitol;Mannidex;Manna sugar;Maniton-S;Diosmol;Mannitol (USP);1,2,3,4,5,6-Hexanehexol;Osmosal;Cordycepic acid;NCI-C50362;Mannit;Mannazucker;Isotol;D-Mannit;Mannitol, Powder;Spray-dried mannitol;D-(-)-Mannitol;
EINECS(EC#)200-711-8
Molecular FormulaC6H14O6
Molecular Weight182.17
Appearancewhite crystalline powder
alpha141 o (C= USP-DIRECTIVES)
refractive index1.333 (20 C)
storage tempStore at RT.
Hazard Xi
Risk R36/37/38
Safety Mildly toxic by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by intravenous route: blood pressure elevation, bladder tubule changes, nausea or vomiting. Human mutation data reported. Used as a nutrient and/or dietary supplement food additive. When heated to decomposition it emits acrid smoke and fumes.
HS Code 29054300
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OP2060000
- CHEMICAL NAME :
- Mannitol, D-
- CAS REGISTRY NUMBER :
- 69-65-8
- BEILSTEIN REFERENCE NO. :
- 1721898
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H14-O6
- MOLECULAR WEIGHT :
- 182.20
- WISWESSER LINE NOTATION :
- Q1YQYQ 2 -BBAA -D
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 17143 mg/kg/2D-C
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9690 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from small intestine
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 50 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States
of America. (National Academy of Sciences, Printing & Pub. Office, 2101
Constitution Ave., Washington, DC 20418) V.1- 1915-
Volume(issue)/page/year: 79,1171,1982
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4308
No. of Facilities: 1555 (estimated)
No. of Industries: 14
No. of Occupations: 31
No. of Employees: 41268 (estimated)
No. of Female Employees: 28689 (estimated)
