Benzofuro[4,3,2-efg][2]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-methoxy-9-methyl-, hydrobromide (9CI) cas no:69353-21-5
Synonyms: Benzofuro[4,3,2-efg]-2-benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide
NameBenzofuro[4,3,2-efg][2]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-methoxy-9-methyl-, hydrobromide (9CI)
CAS69353-21-5
SynonymsBenzofuro[4,3,2-efg]-2-benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide
Molecular FormulaC17H21 N O3 . Br H
Molecular Weight368.31
storage temp?20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard T: Toxic;
Risk R25
Safety
Poison by ingestion, intravenous, and intraperitoneal routes. Used as a cholinesterase inhibitor. When heated to decomposition it emits very toxic fumes of HBr and NOx.Safety information of Galanthamine hydrobromide (CAS NO.69353-21-5):
Hazard Codes: 
T
Risk Statements:
25: Toxic if swallowed
Safety Statements:
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
9mg/kg (9mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Acta Biologica et Medica Germanica. Vol. 7, Pg. 402, 1961. |
| mouse |
LD50 |
intravenous |
5200ug/kg (5.2mg/kg) |
PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
BEHAVIORAL: EXCITEMENT
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Toxicology and Applied Pharmacology. Vol. 3, Pg. 347, 1961. |
| mouse |
LD50 |
oral |
18700ug/kg (18.7mg/kg) |
|
Chemical Abstracts. Vol. 66, Pg. 53993v, 1967. |
| mouse |
LD50 |
subcutaneous |
15400ug/kg (15.4mg/kg) |
PERIPHERAL NERVE AND SENSATION: FASCICULATIONS
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Farmakologiya i Toksikologiya Vol. 25, Pg. 168, 1962. |
| rat |
LD50 |
intravenous |
10mg/kg (10mg/kg) |
|
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 32, Pg. 301, 1986. |
| rat |
LD50 |
oral |
75mg/kg (75mg/kg) |
|
Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 32, Pg. 301, 1986. |
