2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]- cas no:70-22-4

Name2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-
CAS70-22-4
Synonyms2-Pyrrolidinone,1-[4-(1-pyrrolidinyl)-2-butynyl]- (6CI,8CI,9CI);1-(2-Oxopyrrolidinyl)-4-pyrrolidinyl-2-butyne;1-[4-(1-Pyrrolidinyl)-2-butynyl]-2-pyrrolidinone;2'-Oxopyrrolidino-1-pyrrolidino-4-butyne; NSC 330497; Oxotremorin;Oxotremorine; Oxytremorine; Tremorine, oxo-
EINECS(EC#)200-728-0
Molecular FormulaC12H18 N2 O
Molecular Weight206.32

refractive index1.544
storage temp2-8°C

Hazardclass6.1(a)

Hazard T+,C
Risk 28-34
Safety

Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NO_x.

Hazard Codes T+C
Risk Statements 28-34
R28:Very toxic if swallowed. 
R34:Causes burns.
Safety Statements 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2810 6.1/PG 1
WGK Germany 3
RTECS UY5950100
F 10-23
HazardClass 6.1(a)
PackingGroup I

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intravenous	162ug/kg (0.162mg/kg)	LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION	Journal of Pharmaceutical Sciences. Vol. 57, Pg. 1543, 1968.
man	TDLo	oral	7ug/kg (0.007mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	American Journal of Psychiatry. Vol. 144, Pg. 468, 1987.
mouse	LD50	intraperitoneal	3mg/kg (3mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC	Archiv fuer Toxikologie. Vol. 29, Pg. 39, 1972.
mouse	LD50	intravenous	1382ug/kg (1.382mg/kg)		Journal of Medicinal Chemistry. Vol. 28, Pg. 1760, 1985.
mouse	LD50	oral	11300ug/kg (11.3mg/kg)		HHS Publication Vol. FDA-80-1076, Pg. 212, 1980.
rat	LD50	intraperitoneal	4400ug/kg (4.4mg/kg)		Toxicology and Applied Pharmacology. Vol. 14, Pg. 67, 1969.
rat	LD50	intravenous	1220ug/kg (1.22mg/kg)		Fundamental and Applied Toxicology. Vol. 14, Pg. 560, 1990.
women	TDLo	oral	10ug/kg (0.01mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	American Journal of Psychiatry. Vol. 144, Pg. 468, 1987.