Phenol,2,2'-methylenebis[3,4,6-trichloro- cas no:70-30-4

NamePhenol,2,2'-methylenebis[3,4,6-trichloro-
CAS70-30-4
Synonyms2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane;2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane; 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane;2,2'-Methylenebis[3,4,6-trichlorophenol]; AT 7; Acigena; Almederm; B 32;Bilevon; Bis(2-hydroxy-3,5,6-trichlorophenyl)methane;Bis(3,5,6-trichloro-2-hydroxyphenyl)methane; Cotofilm; Dermadex; Distodin;Exofene; Fesia-sin; Fostril; G 11; G 11 (bactericide); Gamophen; Gamophene;Germa-Medica; Hexabalm; Hexachlorofen; Hexachlorophen; Hexachlorophene;Hexafen; Hexophene; Hexosan; NSC 49115; NSC 9887; Nabac; Neosept V; Ritosept;Septisol; Septofen; Soy-Dome; Steral; Steraskin; Surgi-Cen; Surofene;Tersaseptic; pHisoHex
EINECS(EC#)200-733-8
Molecular FormulaC13H6 Cl6 O2
Molecular Weight406.91

Appearanceoff-white to purple powder
refractive index1.67
storage temp2-8°C

Hazardclass6.1(b)

Hazard T: Toxic;N: Dangerous for the environment;
Risk R24/25;R50/53
Safety

A human poison by ingestion. An experimental poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by skin contact. Human systemic effects by ingestion: cardiomyopathy (damage to the heart muscle), nausea or vomiting, diarrhea, shock. Unspecified human reproductive effects. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Strong concentrations may be irritating, but ordinary use of 1–2% solutions is not.
For many years, the toxicologic hazard of hexachlorophene was unrecognized and the compound had a wide and virtually unrestricted use. However, studies by FDA scientists demonstrated that brain lesions occur from exposure in both rats and monkeys treated at levels only slightly higher than those of persons using soaps, toothpaste, shampoos, and a variety of other household products and cosmetics containing it. The FDA has now restricted sale of hexachlorophene, and most preparations containing higher levels of the compound are available only through prescription. In the recent FDA studies, it was found that 2 weeks after onset of exposure, rats fed 500 ppm (25 mg/kg/day) of hexachlorophene in their diet showed weakness in their hindquarters that progressed to paralysis. Microscopic examination of the brain and spinal cord of these rats revealed a particular edema of the white matter resembling spongy degeneration noted in infants. When the animals were removed from the diet, they recovered gradually over a period of weeks. Similar symptoms were noted in monkeys. Following ingestion of hexachlorophene, early symptoms are primarily gastrointestinal in nature and include anorexia, nausea, vomiting, abdominal cramps, and diarrhea. Dehydration is sometimes severe and may be associated with shock.
Used as a germicidal agent. An additive permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals. Also permitted in food for human consumption. When heated to decomposition it emits toxic fumes of Cl⁻. See also CHLOROPHENOLS.
Hazard Codes:
T: Toxic
N: Dangerous for the environment
F: Flammable
Risk Statements about Hexachlorophene (70-30-4):
R11 Highly flammable.
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. 
R52/53: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements about Hexachlorophene (70-30-4):
S20 When using, do not eat or drink.
S37 Wear suitable gloves.
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S60 This material and its container must be disposed of as hazardous waste. 
S61 Avoid release to the environment. Refer to special instructions / safety data sheets.
S36/37: Wear suitable protective clothing and gloves.
Attention:
1. Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
2. Handling: All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

1.		skn-hmn 50 µg/24H MLD		JSCCA5    Journal of the Society of Cosmetic Chemists. 25 (1974),113.
2.		eye-dog 3 mg/24H AAOPAF 53,817,55
3.		skn-rbt 30 µg open MLD		JSCCA5    Journal of the Society of Cosmetic Chemists. 25 (1974),113.
4.		eye-rbt 1500 mg/24H AAOPAF 53,817,55
5.		skn-gpg 30 µg open MLD		JSCCA5    Journal of the Society of Cosmetic Chemists. 25 (1974),113.
6.		skn-gpg 1250 µg/24H MLD		JSCCA5    Journal of the Society of Cosmetic Chemists. 25 (1974),113.
7.		orl-inf TDLo:257 mg/kg/7D-I:CNS,GIT		AJDCAI    American Journal of Diseases of Children. 111 (1966),333.
8.		orl-cld LDLo:250 mg/kg		MJAUAJ    Medical Journal of Australia. 1 (1963),737.
9.		orl-wmn TDLo:600 mg/kg:CVS,GIT		JAMAAP    JAMA, Journal of the American Medical Association. 181 (1962),587.
10.		orl-rat LD50:56 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 25 (1973),332.
11.		ihl-rat LC50:340 mg/m3		GISAAA    Gigiena i Sanita