PEPLEOMYCIN SULFATE cas no:70384-29-1

NamePEPLEOMYCIN SULFATE
CAS70384-29-1
SynonymsNK 631;Peplomycin sulfate;Bleomycinamide,N1-[3-[[(1S)-1-phenylethyl]- amino]propyl]-,sulfate (1:1) (salt);Peplomycin sulfate (JP14/USAN);Pepleo (TN);Pepleo;
EINECS(EC#)274-588-4
Molecular FormulaC₆₁H₉₀N₁₈O₂₅S₃
Molecular Weight1571.67

Safety

Poison by intraperitoneal, subcutaneous, and intravenous routes. Questionable carcinogen with experimental carcinogenic data. An eye irritant. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD	intravenous	> 50mg/kg (50mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" GASTROINTESTINAL: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse	LD50	intraperitoneal	77mg/kg (77mg/kg)		Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse	LD50	intravenous	45mg/kg (45mg/kg)		Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)		Drugs in Japan Vol. 6, Pg. 762, 1982.
mouse	LD50	subcutaneous	80mg/kg (80mg/kg)		Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
mouse	LDLo	intratracheal	1572ng/kg (0.001572mg/kg)	LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL)	Toxicology and Applied Pharmacology. Vol. 56, Pg. 326, 1980.
rat	LD50	intraperitoneal	155mg/kg (155mg/kg)		"Bleomycin: Current Status and New Development, Papers Presented in a Symposium, Oakland, CA, 1977," Carter, S.K., et al., eds., New York, Academic Press, Inc., 1978Vol. -, Pg. 311, 1978.
rat	LD50	intravenous	215mg/kg (215mg/kg)		Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.
rat	LD50	oral	> 2gm/kg (2000mg/kg)		Drugs in Japan Vol. 6, Pg. 762, 1982.
rat	LD50	subcutaneous	199mg/kg (199mg/kg)		Japanese Journal of Antibiotics. Vol. 31, Pg. 719, 1978.