70458-96-7|NorfloxacinProducts Supply - Chemical intermediates Network

Norfloxacin cas no:70458-96-7

Synonyms: 1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid;AM 715;Amicrobin;Baccidal;Barazan;Barotham;Chibroxin;Chibroxine;Esclebin;Floxacin;Floxacin 400;Fulgram;Gonorcin;Lexinor;Mk 0366;N-Demethylpefloxacin;N-Desmethylpefloxacin;Neofloxacin;Neofloxin;Noflo;Nofocin;Nolicin;Noracin;Noraxin;Norbid;Norflox 400;

Identification

NameNorfloxacin
CAS70458-96-7
Synonyms1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid;AM 715;Amicrobin;Baccidal;Barazan;Barotham;Chibroxin;Chibroxine;Esclebin;Floxacin;Floxacin 400;Fulgram;Gonorcin;Lexinor;Mk 0366;N-Demethylpefloxacin;N-Desmethylpefloxacin;Neofloxacin;Neofloxin;Noflo;Nofocin;Nolicin;Noracin;Noraxin;Norbid;Norflox 400;
EINECS(EC#)274-614-4
Molecular FormulaC₁₆H₁₈FN₃O₃
Molecular Weight319.330823

Chemical Properties

AppearanceOff-white to light yellow cryst powder
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Hazard Xn: Harmful;
Risk R20/21/22
Safety

Hazard Codes:? Harmful Xn
Risk Statements: 20/21/22-36/37/38
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 2
RTECS: VB2005000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	oral	> 4gm/kg (4000mg/kg)	?	Journal of Medicinal Chemistry. Vol. 32, Pg. 671, 1989.
man	TDLo	oral	94mg/kg/13D-I (94mg/kg)	MUSCULOSKELETAL: OTHER CHANGES	New Zealand Medical Journal. Vol. 96, Pg. 590, 1983.
mouse	LD50	intramuscular	470mg/kg (470mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Chemotherapy Vol. 29(Suppl,
mouse	LD50	intraperitoneal	1064mg/kg (1064mg/kg)	?	Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991.
mouse	LD50	intravenous	220mg/kg (220mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Chemotherapy Vol. 29(Suppl,
mouse	LD50	oral	4gm/kg (4000mg/kg)	?	Journal of Medicinal Chemistry. Vol. 30, Pg. 2163, 1987.
mouse	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)	?	Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat	LD50	intramuscular	> 500mg/kg (500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Chemotherapy Vol. 29(Suppl,
rat	LD50	intravenous	245mg/kg (245mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Chemotherapy Vol. 29(Suppl,
rat	LD50	oral	> 4gm/kg (4000mg/kg)	?	Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
rat	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)	?	Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984.
women	TDLo	oral	48mg/kg/2D-I (48mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Medical Journal of Australia. Vol. 159, Pg. 423, 1993.
women	TDLo	oral	48mg/kg/2D-I (48mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" BEHAVIORAL: MUSCLE WEAKNESS MUSCULOSKELETAL: JOINTS	Medical Journal of Australia. Vol. 159, Pg. 423, 1993.

supplier list

Hangzhou Starshine Pharmaceutical Co., LTD: Tel:86-571-8696517; Address: Fengqi East Road, Hangzhou, China.

RenSin Chemicals Limited: Tel:+86-25-87702966; Address: 3-810RM, Jiaye international town, 158 Lushan Road,Jianye District,Nanjing 210019, China

XINCHANG GUOBANG IMPORT AND EXPORT CO LTD.: Tel:+86-575-86128944; Address: 5TH FLOOR ,GUOBANG BUILDING , NO.2-12 DONGCHANG W.RD.,XINCHANG ZHEJIANG, P.R.CHINA

YANGZHOU CHEMICAL CO.,LTD.: Tel:86-514-87864167; Address: 7/F,18 WEST WENCHANG ROAD,YANGZHOU,JIANGSU,CHINA

Jiangsu Guotai International Group: Tel:; Address: 10-11/F, Guotai Bldg, 43 Renmin Road, Zhangjiagang, Jiangsu Province, China 215600.

synchem International Co.,Ltd.: Tel:; Address: Room 3208/3209 World Trade Center,No.25 TongXing Street,Zhongshan District,Dalian,China.

Cheng Yi Pharmaceutical Co., Ltd.: Tel:; Address: 118 Hua Gong Rd , Dongping, Dongtou, Zhejing, 325700, P.R.CHINA

Melone Pharmaceutical Co., Ltd.: Tel:; Address: Room 2209锛孨o.232, Jinma Road, Development Zone, Dalian, China

Shanghai Chemivit International Co.,Ltd: Tel:+86-21-58352247; Address: RM104 NO.9(XINGRONG BUILDING),628 NONG ZHANGYANG ROAD,PUDONG,SHANGHAI,CHINA

Enpeak Technology Co. Ltd.: Tel:+86 797 2198786; Address: 301 new office building, commercial park, 22 red flag road, Ganzhou, JiangXi, China

Ningbo Victory & Prosperity Chemistry CO.,LTD.: Tel:+86-(574)-27666767; Address: 21/F, No.11 Bldg, Xin Tian Di, NO 689, Shi Ji Road, NINGBO 315040,

Neuland Laboratories Ltd.: Tel:+91-(40)-23412934; Address: 204, II Floor,Meridian Plaza, 6-3-854/1, Ameerpet, Hyderabad, Andhra Pradesh 500 016,

Matrix Laboratories Ltd.: Tel:+91-(40)-27700363; Address: 1-151/1, IV Floor, Sairam Towers, Alexander Road, Secunderabad, Andhra Pradesh 500 003,

Chengdu Tiantaishan Pharmaceutical Co., Ltd.: Tel:+86-(28)-85198269, 85185992; Address: No.88, Tianxing Street, Qionglai, Sichuan 611531,

Pan India Drugs & Chemicals Ltd.: Tel:+91-(731)-2532548; Address: 415 - 416, Manas Bhawan, 11, R. N. T. Marg, Indore, Madhya Pradesh 452001,

Norfloxacin cas no:70458-96-7

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