mammal (species unspecified) |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
? |
Journal of Medicinal Chemistry. Vol. 32, Pg. 671, 1989. |
man |
TDLo |
oral |
94mg/kg/13D-I (94mg/kg) |
MUSCULOSKELETAL: OTHER CHANGES |
New Zealand Medical Journal. Vol. 96, Pg. 590, 1983. |
mouse |
LD50 |
intramuscular |
470mg/kg (470mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Chemotherapy Vol. 29(Suppl, |
mouse |
LD50 |
intraperitoneal |
1064mg/kg (1064mg/kg) |
? |
Ensho. Japanese Journal of Inflammation. Vol. 11, Pg. 343, 1991. |
mouse |
LD50 |
intravenous |
220mg/kg (220mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Chemotherapy Vol. 29(Suppl, |
mouse |
LD50 |
oral |
4gm/kg (4000mg/kg) |
? |
Journal of Medicinal Chemistry. Vol. 30, Pg. 2163, 1987. |
mouse |
LD50 |
subcutaneous |
> 1500mg/kg (1500mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984. |
rat |
LD50 |
intramuscular |
> 500mg/kg (500mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Chemotherapy Vol. 29(Suppl, |
rat |
LD50 |
intravenous |
245mg/kg (245mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Chemotherapy Vol. 29(Suppl, |
rat |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984. |
rat |
LD50 |
subcutaneous |
> 1500mg/kg (1500mg/kg) |
? |
Yakkyoku. Pharmacy. Vol. 35, Pg. 1625, 1984. |
women |
TDLo |
oral |
48mg/kg/2D-I (48mg/kg) |
BEHAVIORAL: MUSCLE WEAKNESS
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Medical Journal of Australia. Vol. 159, Pg. 423, 1993. |
women |
TDLo |
oral |
48mg/kg/2D-I (48mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
BEHAVIORAL: MUSCLE WEAKNESS
MUSCULOSKELETAL: JOINTS |
Medical Journal of Australia. Vol. 159, Pg. 423, 1993. |