Medroxyprogesterone 17-acetate cas no:71-58-9
Synonyms: Pregn-4-ene-3,20-dione,17-hydroxy-6a-methyl-, acetate(7CI,8CI);Progesterone, 17-hydroxy-6a-methyl-, acetate (6CI);17a-Acetoxy-6a-methylprogesterone;17a-Hydroxy-6a-methyl-4-pregnene-3,20-dione17-acetate;17a-Hydroxy-6a-methylprogesteroneacetate;6a-Methyl-17-acetoxyprogesterone;6a-Methyl-17a-acetoxy-D4-pregnene-3,20-dione;6a-Methyl-17a-acetoxypregn-4-ene-3,20-dione;Amen;CBP 1011;Clinovir;Colirest;Curretab;Cycrin;DMPA;Depo-Prodasone;Depo-Ralovera;Depo-promone;Depomedroxyprogesterone acetate;Farlutal;Farlutin;Lutoral;Medroprogesterone acetate;
NameMedroxyprogesterone 17-acetate
CAS71-58-9
SynonymsPregn-4-ene-3,20-dione,17-hydroxy-6a-methyl-, acetate(7CI,8CI);Progesterone, 17-hydroxy-6a-methyl-, acetate (6CI);17a-Acetoxy-6a-methylprogesterone;17a-Hydroxy-6a-methyl-4-pregnene-3,20-dione17-acetate;17a-Hydroxy-6a-methylprogesteroneacetate;6a-Methyl-17-acetoxyprogesterone;6a-Methyl-17a-acetoxy-D4-pregnene-3,20-dione;6a-Methyl-17a-acetoxypregn-4-ene-3,20-dione;Amen;CBP 1011;Clinovir;Colirest;Curretab;Cycrin;DMPA;Depo-Prodasone;Depo-Ralovera;Depo-promone;Depomedroxyprogesterone acetate;Farlutal;Farlutin;Lutoral;Medroprogesterone acetate;
EINECS(EC#)200-757-9
Molecular FormulaC24H34O4
Molecular Weight386.53
Appearancewhite powder
refractive index1.536
storage tempRefrigerator
Hazard Xn:Harmful
Risk R40;R48
Safety
Hazard Codes: Xn
Risk Statements: 40-48
R40: Limited evidence of a carcinogenic effect
R48: Danger of serious damage to health by prolonged exposur
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: TU5010000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
|
Drugs in Japan Vol. -, Pg. 1196, 1990. |
| mouse |
LD50 |
intraperitoneal |
> 1500mg/kg (1500mg/kg) |
|
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| mouse |
LD50 |
oral |
> 16gm/kg (16000mg/kg) |
ENDOCRINE: ADRENAL CORTEX HYPOPLASIA |
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| mouse |
LD50 |
subcutaneous |
> 1500mg/kg (1500mg/kg) |
|
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| rat |
LD50 |
intraperitoneal |
> 900mg/kg (900mg/kg) |
|
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| rat |
LD50 |
oral |
> 6400mg/kg (6400mg/kg) |
LIVER: OTHER CHANGES |
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| rat |
LD50 |
subcutaneous |
> 900mg/kg (900mg/kg) |
|
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984. |
| women |
TDLo |
intravenous |
10mg/kg (10mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE |
Advances in Planned Parenthood. Vol. 8, Pg. 103, 1972. |
| women |
TDLo |
intravenous |
21mg/kg (21mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE |
Advances in Planned Parenthood. Vol. 8, Pg. 103, 1972. |
