Lincomycin hydrochloride monohydrate cas no:7179-49-9
Synonyms: D-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride, monohydrate, trans-a- (8CI);D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,monohydrochloride, monohydrate, (2S-trans)-;Methyl 6,8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride monohydrate;Lincomycin, hydrochloride hydrate;Lincomycin HCL;
NameLincomycin hydrochloride monohydrate
CAS7179-49-9
SynonymsD-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride, monohydrate, trans-a- (8CI);D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,monohydrochloride, monohydrate, (2S-trans)-;Methyl 6,8-dideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside monohydrochloride monohydrate;Lincomycin, hydrochloride hydrate;Lincomycin HCL;
EINECS(EC#)212-726-7
Molecular FormulaC18H34N2O6S.HCl.H2O
Molecular Weight452.00
AppearanceWhite powder
storage temp2-8°C
Hazard Xi: Irritant;
Risk R36/37/38
Safety
Hazard Codes:?
Xi
Risk Statements: 36/37/38?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS: RH6315500
Poison by intravenous route. Moderately toxic by intraperitoneal route. Used as an antibacterial agent. When heated to decomposition it emits toxic fumes of SOx, NOx, and HCl.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
1gm/kg (1000mg/kg) |
? |
"Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. |
| mouse |
LD50 |
intravenous |
214mg/kg (214mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 891, 1982. |
| rat |
LD50 |
intravenous |
342mg/kg (342mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 891, 1982. |
| rat |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
? |
"Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971. |
| rat |
LD50 |
subcutaneous |
9778mg/kg (9778mg/kg) |
? |
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 65, 1969. |
| women |
TDLo |
oral |
192mg/kg/8D-I (192mg/kg) |
BLOOD: NORMOCYTIC ANEMIA |
Postgraduate Medical Journal. Vol. 59, Pg. 796, 1983. |
