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19-Norpregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy-, (17a)- cas no:72-33-3

Synonyms: 19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy- (6CI,8CI);17-Ethynylestradiol 3-methyl ether;17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol;17a-Ethynylestradiol 3-methyl ether;3-Methoxy-17a-ethinylestradiol;3-Methoxyethynylestradiol;3-O-Methyl-17a-ethynylestradiol;33355;Devocin;EE 3ME;Ethynylestradiol 3-monomethyl ether;Inostral;Mestranol;Ovastol;

Identification
Name19-Norpregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy-, (17a)-
CAS72-33-3
Synonyms19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol,3-methoxy- (6CI,8CI);17-Ethynylestradiol 3-methyl ether;17a-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17b-ol;17a-Ethynylestradiol 3-methyl ether;3-Methoxy-17a-ethinylestradiol;3-Methoxyethynylestradiol;3-O-Methyl-17a-ethynylestradiol;33355;Devocin;EE 3ME;Ethynylestradiol 3-monomethyl ether;Inostral;Mestranol;Ovastol;
EINECS(EC#)200-777-8
Molecular FormulaC21H26O2
Molecular Weight310.47
Chemical Properties
Appearancecrystalline solid
refractive index1.49
storage temp-20°C Freezer
Safety Data

Hazard Xn: Harmful;
Risk R36/37/38;R40;R48
Safety

Confirmed carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by subcutaneous route. Human reproductive effects by ingestion: changes in ovaries and fallopian tubes, fertility effects. Experimental reproductive effects. Mutation data reported. An FDA proprietary drug. A steroid used in oral contraceptives. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information
Hazard Codes: Xn?Harmful
Risk Statements: 36/37/38-40-48-68?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R40: Limited evidence of a carcinogenic effect.?
R48: Danger of serious damage to health by prolonged exposure.
R68: Possible risk of irreversible effects.
Safety Statements: 22-26-36/37/39-45-36/37?
S22: Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: RC8960000
?


Toxicity
1. ???

oms-mus-scu 120?μg/kg

??? AJOGAH ?? American Journal of Obstetrics and Gynecology. 120 (1974),390.
2. ???

scu-mus LD50:2500?mg/kg

??? OYYAA2 ?? Oyo Yakuri. Pharmacometrics. 4 (1970),217.

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