72956-09-3|CarvedilolProducts Supply - Chemical intermediates Network

Carvedilol cas no:72956-09-3

Synonyms: 1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano; COREG; DIMITONE; DQ-2466; DILATREND; BM-14190; 1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL; 1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol; Carvedilo; CarvedilolC24H26N204; Carvediloledmf/Gmpep5; CarvedilolEdmf/Gmp; CarvedilolEp5

Identification

NameCarvedilol
CAS72956-09-3
Synonyms1-(9h-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-2-propano; COREG; DIMITONE; DQ-2466; DILATREND; BM-14190; 1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL; 1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol; Carvedilo; CarvedilolC24H26N204; Carvediloledmf/Gmpep5; CarvedilolEdmf/Gmp; CarvedilolEp5
Molecular FormulaC24H26N2O4
Molecular Weight406.48

Chemical Properties

Appearancecolourless crystalline powder
storage tempStore at +4°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Hazard N: Dangerous for the environment;Xn: Harmful;
Risk 51/53-36/37/38-20/21/22
Safety

Hazard Codes of Carvedilol (CAS NO.72956-09-3):? Dangerous N, Harmful Xn
Risk Statements: 51/53-36/37/38-20/21/22
R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 61-36-26
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.?
S36: Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 3077 9/PG 3
RTECS: UA8670000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 1gm/kg (1000mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
mouse	LD50	intraperitoneal	364mg/kg (364mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse	LD50	intravenous	27mg/kg (27mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES	New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
mouse	LDLo	oral	8gm/kg (8000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.
rat	LD50	intraperitoneal	769mg/kg (769mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat	LD50	intravenous	25mg/kg (25mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES	New Cardiovascular Drugs. Vol. 5, Pg. 135, 1987.
rat	LDLo	oral	8gm/kg (8000mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 1181, 1989.

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Carvedilol cas no:72956-09-3

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