Melatonine cas no:73-31-4
Synonyms: N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide;N-Acetyl-5-methoxytryptamine;5-Methoxy-N-acetyltryptamine;Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-;acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-;N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide;Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI);Melovine;Acetamide, N-[2- (5-methoxy-1H-indol-3-yl)ethyl]-;Melatonin;Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-};Circadin;Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)- ethyl]-;Prestwick_312;Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI);Melatonin (MLT);
NameMelatonine
CAS73-31-4
SynonymsN-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide;N-Acetyl-5-methoxytryptamine;5-Methoxy-N-acetyltryptamine;Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-;acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-;N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide;Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI);Melovine;Acetamide, N-[2- (5-methoxy-1H-indol-3-yl)ethyl]-;Melatonin;Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-};Circadin;Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)- ethyl]-;Prestwick_312;Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI);Melatonin (MLT);
EINECS(EC#)200-797-7
Molecular FormulaC13H16N2O2
Molecular Weight232.31 g/mol
AppearanceWhite crystalline powder
storage temp-15°C
Hazard T: Toxic;
Risk R60
Safety
Hazard Codes:?
T?
Risk Statements: 60?
R60: May impair fertility.
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.?
WGK Germany: 2?
RTECS: AC5955000
F: 8-10-23
HS Code 29379000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
1375mg/kg (1375mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 17, Pg. 559, 1983. |
| mouse |
LD50 |
intravenous |
180mg/kg (180mg/kg) |
? |
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02739, |
| mouse |
LD50 |
oral |
1250mg/kg (1250mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
| mouse |
LD50 |
subcutaneous |
> 1600mg/kg (1600mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
| rat |
LD50 |
intraperitoneal |
1131mg/kg (1131mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
| rat |
LD50 |
intravenous |
356mg/kg (356mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
| rat |
LD50 |
oral |
> 3200mg/kg (3200mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
| rat |
LD50 |
subcutaneous |
> 1600mg/kg (1600mg/kg) |
? |
Journal of Pharmacology and Experimental Therapeutics. Vol. 227, Pg. 587, 1983. |
?Melatonin (CAS NO.73-31-4) has a very low toxicity in rats. Rat maternal toxicity: the no observable adverse effect level (NOAEL) and lowest observed adverse effect level (LOAEL) were 100 and 200 mg/kg/day, respectively, and the developmental toxicity NOAEL was >= 200 mg/kg/day.
