dog |
LD50 |
unreported |
> 600mg/kg (600mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 33, Pg. 782, 1991. |
man |
TDLo |
oral |
4mg/kg/2W-I (4mg/kg) |
MUSCULOSKELETAL: JOINTS |
Lancet. Vol. 345, Pg. 461, 1995. |
mouse |
LD50 |
intraperitoneal |
> 100mg/kg (100mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
mouse |
LD50 |
intravenous |
82800ug/kg (82.8mg/kg) |
? |
Scandinavian Journal of Gastroenterology, Supplement. Vol. 108, Pg. 53, 1985. |
mouse |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
mouse |
LD50 |
subcutaneous |
> 100mg/kg (100mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
rat |
LD50 |
intraperitoneal |
> 100mg/kg (100mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
rat |
LD50 |
intravenous |
> 50mg/kg (50mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
rat |
LD50 |
oral |
2210mg/kg (2210mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
rat |
LD50 |
subcutaneous |
> 100mg/kg (100mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Oyo Yakuri. Pharmacometrics. Vol. 36, Pg. 369, 1988. |
women |
TDLo |
oral |
800ug/kg/2D-I (0.8mg/kg) |
LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION
LUNGS, THORAX, OR RESPIRATION: COUGH |
Pharmacotherapy Vol. 14, Pg. 119, 1993. |
women |
TDLo |
oral |
4400ug/kg/11D (4.4mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION |
American Journal of Gastroenterology. Vol. 94, Pg. 1119, 1999. |
women |
TDLo |
oral |
24mg/kg/60D-I (24mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: NORMOCYTIC ANEMIA |
Postgraduate Medical Journal. Vol. 74, Pg. 416, 1998. |
women |
TDLo |
oral |
30mg/kg/10W-I (30mg/kg) |
BLOOD: EOSINOPHILIA
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
American Journal of Medicine. Vol. 95, Pg. 248, 1993. |
women |
TDLo |
oral |
36400ug/kg/13 (36.4mg/kg) |
BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE |
Journal of Clinical Gastroenterology. Vol. 25, Pg. 718, 1997. |