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xylazine free base cas no:7361-61-7

Synonyms: Xylazine (free base); Xylazine base; xylazine

Identification
Namexylazine free base
CAS7361-61-7
SynonymsXylazine (free base); Xylazine base; xylazine
EINECS(EC#)230-902-1
Molecular FormulaC12H16N2S
Molecular Weight220.33
Chemical Properties
storage temp−20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard T:Toxic;
Risk R25
Safety

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.
 

Hazard Codes: T
Risk Statements:
25:  Toxic if swallowed
Safety Statements:
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 18mg/kg (18mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#10054,
mouse LD50 oral 240mg/kg (240mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
mouse LD50 subcutaneous 121mg/kg (121mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
rat LD50 oral 130mg/kg (130mg/kg)   Deutsche Tieraerztliche Wochenschrift. Vol. 75, Pg. 565, 1968.
women TDLo intramuscular 734ug/kg (0.734mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
CARDIAC: PULSE RATE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
 
women TDLo intramuscular 22mg/kg (22mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
CARDIAC: PULSE RATE
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
American Journal of Emergency Medicine. Vol. 4, Pg. 222, 1986.
 
women TDLo oral 8mg/kg (8mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
CARDIAC: PULSE RATE
Clinical Toxicology. Vol. 18, Pg. 663, 1981.

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